Twin with ME/CFS wants to be a research subject

[Utsikt]

I was wandering about the obvious things such a different sex twins (or more), something most people will have come across in their lives, which per definition cannot be identical.

There are very rare exceptions:

Monozygotic twins of opposite sex - PubMed

Although discordant karyotypes are known in identical twins, cases involving differences in sex phenotype are rare. We studied identical twins with the 46,XY karyotype - a male with mixed gonadal dysgenesis and a female with "pure" gonadal dysgenesis. The testis-determining SRY gene was present...

pubmed.ncbi.nlm.nih.gov

 

[Sasha]

I have always used 'twins' for both types, identical and non-identical or monoygotic and dizygotic.
He is potentially of interest whichever in that studies often make use of differences in concordance between the two types. If only a small number of pairs are available then dizygotics would probably be more interesting to see which uncommon genes might show up in only affected individuals.

Wouldn't you need a whole ton of them, though?

 

[Jonathan Edwards]

Wouldn't you need a whole ton of them, though?

You tend to need quite a lot for any genetic statistical study. However, one person in forty is a twin. Of the 16000 people in DecodeME 400 should be twins. The big problem with genetic screening studies like GWAS is that you have to make such big corrections to your p values to avoid false positives. Once you know what genes you are interested in - maybe ten instead of ten thousand - then numbers needed are a lot smaller, ay least as I understand it.