Upadacitinib (rinvoq)--could it reduce fatigue in ME/CFS?

https://en.wikipedia.org/wiki/Upadacitinib
https://www.rinvoq.com/

Janus kinase inhibitor that is selective for the JAK1 subtype of this enzyme--for the treatment of RA


@Jonathan Edwards Any chance that this might also work for ME/CFS?

I ask because I am bombarded with TV commercials for Rinvoq where they say that it can significantly reduce the fatigue found in RA.

I think you said elsewhere that RA fatigue might be physiologically different from MECFS fatigue?



Thanks.

 

Lots of different treatments that reduce cytokine-driven inflammation in RA reduce fatigue. A Janus kinase inhibitor would work through that route so would be expected to reduce fatigue. But that means we only expect it to reduce fatigue in conditions with cytokine-driven inflammation. Cytokine-driven inflammation is reasonably well indicated by CRP levels - which are normal in ME. So there does not appear to be any cytokine-driven inflammation in ME and we would not expect a Janus kinase inhibitor to help.

There are possible exceptions to this argument but at present I don't think we have much to suggest they apply.

 

https://www.medpagetoday.com/rheumatology/arthritis/89124


Upadacitinib, Abatacept Go Head to Head in RA