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Upadacitinib (rinvoq)--could it reduce fatigue in ME/CFS?

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Jaybee00, Aug 17, 2020.

  1. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    https://en.wikipedia.org/wiki/Upadacitinib
    https://www.rinvoq.com/

    Janus kinase inhibitor that is selective for the JAK1 subtype of this enzyme--for the treatment of RA


    @Jonathan Edwards Any chance that this might also work for ME/CFS?

    I ask because I am bombarded with TV commercials for Rinvoq where they say that it can significantly reduce the fatigue found in RA.

    I think you said elsewhere that RA fatigue might be physiologically different from MECFS fatigue?



    Thanks.
     
    Woolie, MEMarge, sebaaa and 1 other person like this.
  2. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    Lots of different treatments that reduce cytokine-driven inflammation in RA reduce fatigue. A Janus kinase inhibitor would work through that route so would be expected to reduce fatigue. But that means we only expect it to reduce fatigue in conditions with cytokine-driven inflammation. Cytokine-driven inflammation is reasonably well indicated by CRP levels - which are normal in ME. So there does not appear to be any cytokine-driven inflammation in ME and we would not expect a Janus kinase inhibitor to help.

    There are possible exceptions to this argument but at present I don't think we have much to suggest they apply.
     
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  3. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    MEMarge likes this.

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