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Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19, 2023, Rousseau+

Discussion in 'Long Covid research' started by EndME, Oct 25, 2023.

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  1. EndME

    EndME Senior Member (Voting Rights)

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    Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19 (BQC-19)

    The quest for understanding and managing the long-term effects of COVID-19, often referred to as Long COVID or post-COVID-19 condition (PCC), remains an active research area. Recent findings highlighted angiopoietin-1 (ANG-1) and p-selectin (P-SEL) as potential diagnostic markers, but validation is essential, given the inconsistency in COVID-19 biomarker studies. Leveraging the biobanque québécoise de la COVID-19 (BQC19) biobank, we analyzed the data of 249 participants.

    Both ANG-1 and P-SEL levels were significantly higher in patients with PCC participants compared with control subjects at 3 months using the Mann-Whitney U test.

    We managed to reproduce and validate the findings, emphasizing the importance of collaborative biobanking efforts in enhancing the reproducibility and credibility of Long COVID research outcomes.


    https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/s12014-023-09436-7
     
    EndME, Oct 25, 2023
    #1
    Hutan, LarsSG and cassava7 like this.
  2. EndME

    EndME Senior Member (Voting Rights)

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    Validating some of the findings of Douglas Frasers team whose work and choice of cohort (predominantly older, a slight majority of males, often with pre-existing conditions, with predominantly respiratory and coughing problems) has been discussed here:
    The interesting question now will be how exactly the validation cohort looks like and which markers correlate with which subgroup of that validation cohort.
     
    EndME, Oct 25, 2023
    #2
    Hutan, obeat, alktipping and 1 other person like this.
  3. LarsSG

    LarsSG Senior Member (Voting Rights)

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    They really don't give you much with only a median and Mann-Whitney values, but it does look like something.

    I guess what's needed now is to repeat this in another chronic illness control group, to see if this is meaningfully about LC or just a general marker of illness.
     
    LarsSG, Oct 30, 2023
    #3
    Hutan likes this.
  4. Hutan

    Hutan Moderator Staff Member

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    Location:
    Aotearoa New Zealand
    The control cohort is also post-infection.
    The PCC cohort here has fewer people over 65 (18%) than the control cohort (25%).
    Also 59% female versus only 46% female in the control cohort
    Still a high hospitalisation rate compared to the controls (58% versus 34%), although it is claimed that 55% of the PCC cohort had a mild acute illness. 69% of the control cohort had a mild acute illness.

    So, there is still some doubt about whether the ANG-1 and P-SEL measures might have something to do with increased illness severity rather than PCC/Long Covid. But the findings seem resilient to the sex and age characteristics of the cohorts.
     
    Last edited: Oct 31, 2023
    Hutan, Oct 31, 2023
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    SNT Gatchaman and EndME like this.
  5. Hutan

    Hutan Moderator Staff Member

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    27,997
    Location:
    Aotearoa New Zealand
    The reported persisting symptoms seem quite odd - the percentages reporting each were mostly much lower than I'm used to seeing in Long Covid cohorts.
    49.7% reported fatigue; 33.1% reported breathlessness; 20.1% reported joint pain. 41% reported 'anxiety and depression'; loss of taste and smell 20.9%.
     
    Last edited: Oct 31, 2023
    Hutan, Oct 31, 2023
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    EndME likes this.

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