Variants in water channel gene tied to more restful sleep (The Scientist--article)

Snowdrop · May 25, 2020

Research on rodents.

https://www.the-scientist.com/news-...channel-gene-tied-to-more-restful-sleep-67529

In a paper published May 5 in PLOS Biology, researchers connect the dots between AQP4 and sleep in people. They showed that individuals with a set of eight single nucleotide polymorphisms (SNPs) in AQP4 have more slow wave energy as they sleep, which is characteristic of deep states of slumber, than those without the variants. And they have better cognitive function after being sleep deprived than people without those SNPs.
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Paper here

spinoza577 · May 26, 2020

Might be key for my ME, according to some recent experiences I still have.

from the introduction

The gene encoding AQP4 is located on chromosome 18 (18q11.2–q12.1) [13] (Fig 1). Several thousand single nucleotide polymorphisms (SNPs) in the noncoding regions of AQP4 have so far been identified, and their function(s) in the normal and diseased human brain is an active area of research. Human AQP4 SNPs have been shown to impair cellular water permeability and water homeostasis in vitro [14]. Moreover, an array of studies have associated human AQP4 SNPs with neurological disorders including Alzheimer’s disease progression [15], vascular depression phenotype [16], leukariosis [17], outcome after traumatic head injury [18], edema formation [19,20], and the risk of stroke [21]. These findings suggest a link between AQP4 and the development of brain diseases associated with waste deposition and fluid movements. Recently, a single variant within AQP4 was associated with a 15% to 20% change in AQP4 expression [22].
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Madbeggar · Mar 27, 2023

ETA links and winks.

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation, 2023.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995113/

Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases, 2023.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965491/
This suggests wearing night-time headgear with 600–1300 nm LEDs, but it should include a cooling system to ameliorate the heat they'd create. (I'm off to the workshop now )

NelliePledge · Mar 27, 2023

Madbeggar said: ↑

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation, 2023.
Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases, 2023.
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do you have a link you can post?

Madbeggar · Mar 27, 2023

NelliePledge said: ↑

do you have a link you can post?
Click to expand...

Done.

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Variants in water channel gene tied to more restful sleep (The Scientist--article)

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