Researcher Interactions Video: Science for ME Q&A with Dr Karl Morten, University of Oxford, Sept 2019 - Part 1 and 2

Andy

Andy

Senior Member (Voting rights)
Delighted to release our latest Q&A. I have split it into two parts due to the length of the conversation.

Part one - Acumen/Myhill Test discussed | Processing of samples | Details from his NZ presentation

Copy-and-paste
Code: 
https://youtu.be/CfON3BVOuW8



Part two - Something in the blood | MRC application | Plans for future research

Copy-and-paste
Code: 
https://youtu.be/5_BE-qdrS00

 
Thanks Andy and Karl Morten for this. I found it all very interesting.

One thing that strikes me from having just watched the Stanford Symposium over the last couple of days is that it would be good if Karl could meet up with a wider range of researchers to exchange ideas.
 
@Andy Thank you for this Q&A. This interaction is very useful and may help speed things up. I sincerely hope this Q&A series continue with other researchers as well.

20:02 (Part One ): Dr Morten says that they can differentiate with 100% accuracy between ME patients and controls on a polish cohort based on Glutamate/glutamine metabolites. Very interesting but does require further inspection

I was also happy to hear that Dr Morten is thinking in terms of patient segments/clusters.
 
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Sarah94 said:
If anyone is able to summarise or transcribe I would be super grateful
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Fingers crossed that someone else will be able to do this, I'm afraid I'm on to the next job already.

mariovitali said:
I sincerely hope this Q&A series continue with other researchers as well.
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It's certainly my intention to, I'll keep doing them as long as I can find those researchers who are willing and able to take part. :)
 
The reason that oxygen levels start high and drop sharply right after is because the machine that controls the oxygen levels in the medium is turned on or begins taking effect. These reduced oxygen levels more closely reflect physiological levels. That's how I understood it anyway.

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Morten also provided further information on this experiment and said he doesn't see the effect with heparinized blood, that cancer cells react differently, and that a similar effect is seen when glycosis is inhibited. I was very tired while listening to this part and hope I didn't write anything wrong.

Edit: mnore accurately he said:

If you block glucose metabolism at the level of glycolysis and prevent it from going into the mitochondria you see something very similar to what can be seen in the graph, which gives him some ideas about ME/CFS.

He also thinks that oxygen consumption reflects mitochondrial activity, unlike Ron Davis nanoneedle test where it's not clear what is being measured.
 
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Hi, I just watched the second video. Dr Morten mentioned they are working with Dr Oltra in Valencia. He also says they're thinking of crowd funding some projects. Being a Spanish resident I can reclaim a whopping 75% of charity/public university etc donations for the first 150e and 30% after that.

Would be great if I could donate in Spain for any crowd funding. Can someone @ me if they set up anything and I'll post it on the Spanish ME group sites

Cheers!
 
mariovitali said:
@Andy Thank you for this Q&A. This interaction is very useful and may help speed things up. I sincerely hope this Q&A series continue with other researchers as well.

20:02 (Part One ): Dr Morten says that they can differentiate with 100% accuracy between ME patients and controls on a polish cohort based on Glutamate/glutamine metabolites. Very interesting but does require further inspection

I was also happy to hear that Dr Morten is thinking in terms of patient segments/clusters.
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How big was this cohort?
 
Andy said:
Fingers crossed that someone else will be able to do this, I'm afraid I'm on to the next job already.
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I remember reading youtube can do some auto-transcription thing, to produce subtitles... but when I tried to use this I wasted a lot of time and achieved nothing. That could show it's difficult to do, or just that I'm an idiot.
 
Esther12 said:
I remember reading youtube can do some auto-transcription thing, to produce subtitles... but when I tried to use this I wasted a lot of time and achieved nothing. That could show it's difficult to do, or just that I'm an idiot.
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They can do this but they get a LOT of words wrong.
 
Sarah94 said:
They can do this but they get a LOT of words wrong.
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I expect correcting those words would be a lot easier than starting afresh. I need to work out how to do use this as I never really understood why I kept failing last time.
 
Esther12 said:
I expect correcting those words would be a lot easier than starting afresh. I need to work out how to do use this as I never really understood why I kept failing last time.
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I've just tried. I clicked on the video, then clicked on ''You Tube'' at the bottom, so I was seeing the video on the You Tube channel, then clicked on ''CC'' at the bottom and the subtitles came on.
Edit: I don't know how to turn that into a transcript.
 
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