ME/CFS Science Blog
Senior Member (Voting Rights)
Do less viruses in the blood of ME/CFS patients mean something about their immune system or is the most likely explanation less contact with other people and therefore less exposure to viruses?
Preprint Virus Genome Sequences in the Blood of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients, 2025, Davis et al
neophyte32
Established Member (Voting Rights)
What do u mean ? It s a bad news or this research is not very important for the future ?
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mariovitali
Senior Member (Voting Rights)
Of course it may well be what @ME/CFS Science Blog suggests : Fewer contacts of patients means that the probability of infection is very low. However, I would like to mention a subset of ME/CFS patients who say that ever since they gotten ME/CFS they do not get viral infections at all. I wonder whether this is a clue and this subset may be deserving more attention.
It is possible (?) that we are looking at impaired N-Linked glycosylation which is a key mechanism used by enveloped viruses to attach to a host. I believe there is only one study at the moment which is looking at glycosylation function in ME/CFS patients
It is possible (?) that we are looking at impaired N-Linked glycosylation which is a key mechanism used by enveloped viruses to attach to a host. I believe there is only one study at the moment which is looking at glycosylation function in ME/CFS patients
Utsikt
Senior Member (Voting Rights)
Probably a nail in the coffin for the viral persistence theory for ME/CFS
neophyte32
Established Member (Voting Rights)
It’s a bit hard to hear, because in the case of LC and ME/CFS, most of the NIH funding, for example, is allocated to viral persistence...
Utsikt
Senior Member (Voting Rights)
Yeah, it’s a colossal waste of time and resources. Luckily there are some good ME/CFS researchers that are looking elsewhere!
Our gut is full of all sorts of phages, so wouldn't the rest of our body be too? Our gut immune cells apparently grab bacteria (and maybe other microbes?) and drag them to our (was it thymus?) glands to teach new cells to ignore them. "Hey class: meet G45d565treew55yu. He's a good guy!" So, are the beneficial microbes populating us considered "infections"? I really like those bacteria (mitochondria) infecting my cells.
Do beneficial viruses exist in our cells? That would complicate studies of this type, especially if specific viruses were beneficial in specific individuals, and detrimental in others.
https://sciencedaily.com/releases/2025/11/251102205009.htm
"The researchers studied bacteria that carry extremely old, inactive viruses and found that these dormant invaders still play a protective role." Maybe our cells have these too. Isn't a lot of our DNA old viral fragments? More DNA/RNA to mess up studies if they're not accounted for properly.
"The researchers studied bacteria that carry extremely old, inactive viruses and found that these dormant invaders still play a protective role." Maybe our cells have these too. Isn't a lot of our DNA old viral fragments? More DNA/RNA to mess up studies if they're not accounted for properly.
It's not dead yet.
Utsikt
Senior Member (Voting Rights)
Google says 8 % is from viruses, and another 40 % is just repeating letters thought to also be from viruses. No idea if that could lead to false positives in those experiments.