What degree of change do we want from an effective treatment for ME/CFS?

[Evergreen]

treatments that only target certain facets

Yes please!

Any improvement is welcomed although to really change my life its got to be a full step up in severity, about +1 funcap or 20% bell. but I think the heart of the problem is what is actually a real improvement from treatment and not just positivity bias or factors of the questionaire.

Yeah, I don't want hype. I want unambiguous, big jumps in functioning in really well-designed controlled studies, so that we know we're not just seeing natural fluctuations mixed with good cheer.

But honestly I want no PEM. I want to be able to hike and ride horses again.

Yeah, aim high, why not? I have just been worn down by the years. Faced with promising research, I might start getting grabby again.

Reduced pain and less skewed sleeping patterns would make a big difference to my capacity to do physical and cognitive activity and consequently increase my quality of life.

Mmm, reduced pain.