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The discussion about the NIH and Francis Collins has been moved here: USA: NIH National Institute of Health The discussion about Trisha Greenhalgh and her Canadian webinar presentation has been moved here: Trisha Greenhalgh on ME/CFS and Long Covid The discussion about vaccinations has been...

Actually I could be quite easily persuaded to believe that CBT does have some uses - in conditions where the world might in fact be being viewed unhelpfully e.g. aggression, anxiety disorders and phobias. And, in Figure 2 of this meta-review, reviews of studies of anxiety disorders do appear to...

You would think, given the extremely high rate of low quality reviews, that there might have been some comment about what was wrong with the reviews, or some comment about how future reviews might be done. But, no. There was nothing at all said about the reliance on subjective outcomes with...

This sounds awful. There's a short video at the link. 'Common syndromes' are mentioned, with IBS and fibromyalgia given as examples. The closest the list on the accompanying slide comes to ME/CFS is 'fatigue'. It makes no sense to look retrospectively at the patients who were sent for tests...

Not wanting to take the thread off topic, but me too - they are quite expensive, but mine was my best purchase of 2020. It does a couple of runs a week and has been the answer to the drifts of dog hair that used to accumulate in some corners and under furniture. I still get a disproportionate...

This is a wonderful opportunity. @Chris Ponting or @Andy, will the person selected have to live in Edinburgh?

Notification of a PhD opportunity in Edinburgh has been moved to the Recruitment subforum: January 2021 United Kingdom: PhD opportunity - ME/CFS & Long Covid: Genetics, Truth and Reconciliation

I understand. But it does not sound as though someone has to have all of the signs, such as the skin signs, to be diagnosed. I guess my point is that a particular syndrome might be very tightly defined by some clinicians, excluding people who don't have a particular sign that the clinician...

ME/CFS does follow Q fever, and the cause of Q fever, Coxiella burnetii, is an intracellular bacteria. But I expect you know that Jonathan. Have I misunderstood your point? (Wikipedia tells me 'The genus Coxiella is morphologically similar to Rickettsia, but with a variety of genetic and...

It's things like Reiters and Behcet's that make me wonder why there is so much skepticism about ME/CFS being a physical illness. The definition of Reiters and Behcet's both seem quite vague, with various symptoms coming and going. If these post-infectious illnesses are accepted, why is it so...

Link to a thread on an article about the link between Covid-19 and ME/CFS by Komaroff and Bateman: Will COVID-19 Lead to ME/CFS?, Komaroff and Bateman, 2021

Posts discussing autoimmunity and the role of t-cells in ME/CFS have been moved to a new discussion thread: The possibility of autoimmunity or auto-reactivity in ME/CFS

Because I have had Graves eye disease, I have been keeping an eye (ha) on the papers that come out. There have been hypotheses about T cell involvement for a while now - this is a recent (2019) article: The involvement of T cell pathogenesis in thyroid-associated ophthalmopathy It sounds more...

From chapter 9: :confused:

I had a couple of flares of Graves Eye Disease prior to developing ME/CFS - seemingly not related to thyroid function in my case. That might be another disease where auto-reactive t-cells can cause their problems quite locally...

30 years ago, it was probably perfectly good science to do studies of drugs aiming to control 'breast cancer', using women with 'breast cancer' as participants. If a drug improved overall outcomes, then the statistics suggested that women had better odds with the drug. It was useful...

There's this 2013 study: Mild Cold Exposure Modulates Fibroblast Growth Factor 21 (FGF21) Diurnal Rhythm in Humans: Relationship between FGF21 Levels, Lipolysis, and Cold-Induced Thermogenesis https://academic.oup.com/jcem/article/98/1/E98/2823412 It suggests that FGF21 varies a lot over the...

It is interesting. But these two results (both in blood) seem at odds with each other.

The reason why we went for in the ME/CFS Canterbury material and why I think the Emerge information is good: is that these talk about 'what researchers are finding'. We are still some way off really nailing down what is going on. Until then, we should avoid being definitive about things like...

Discussion of the BMJ Editorial by Stokes and Wade has been moved to a new thread: BMJ editorial: Updated NICE Guideline on chronic fatigue syndrome, 2020, Stokes and Wade