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    The impact of sex differences on perceived pain intensity in pain protocol standardization, 2024, Wragan et al

    Preprint Abstract Background: Sex differences have been widely demonstrated in both acute and chronic pain. Sex differences may have wider impact on research design and analysis than already established. This study addresses an important methodological aspect with regards to how sex differences...
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    A description of the development of an innovative multi-component [LC] treatment program based on central sensitization, 2024, Munipalli+

    Also, In other words, more than 80% of patients showed no sign of pain catastrophizing, despite having a serious disabling illness. But they're being told their problems are due to 'maladaptive cognition' anyway.
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    A description of the development of an innovative multi-component [LC] treatment program based on central sensitization, 2024, Munipalli+

    We should be grateful that at least their grab-bag of 'strategies' doesn't include 'go stick your head in a pig'.
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    Preprint Smartphone-based monitoring of heart rate variability and resting heart rate predicts variability in symptom exacerbations..., 2024, Aitken+

    Garner's understanding of classical conditioning seems to be that the dog's salivating causes the food to arrive.
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    Preprint Smartphone-based monitoring of heart rate variability and resting heart rate predicts variability in symptom exacerbations..., 2024, Aitken+

    My Fitbit also gave me scarily low HRV readings, so I looked on their community forums and saw lots of other people saying theirs were also giving scarily low readings compared to what their other devices were telling them. I think it's just a fitbit 'thing' and probably the key is to look at...
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    Doxophylline, a Non-Selective Phosphodiesterase Inhibitor, Protects Against Chronic Fatigue-Induced Neurobehavioral,... 2024 Kumar et al

    At least they didn't give the mice questionnaires afterwards to see if the swimming exercise produced improvements on self-reported fatigue scores.
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    Doxophylline, a Non-Selective Phosphodiesterase Inhibitor, Protects Against Chronic Fatigue-Induced Neurobehavioral,... 2024 Kumar et al

    "a state of CFS in mice was induced by forcing them to swim daily for 6 min for 15 days" distressing and pointless
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    COFFI - The international collaborative on fatigue following infection

    Evolutionary adaptation is just something that happened to other people...
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    Do you get breathless with exertion?

    Yes (ME triggered by Covid) - both physical and mental exertion leave me short of breath now. I'm not overweight, mid 40s and no other medical conditions.
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    Altered Neural Processing of Interoception in Patients With Functional Neurological Disorder: A Task-Based fMRI Study 2024 Sojka et al

    A finding of reduced neural activation during interoceptive tasks would seem to conflict with the hypothesis that FND patients are paying too much attention to interoceptive signals and becoming overly sensitised?
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    UK House of Lords/ House of Commons Questions

    Somebody could usefully ask how many of those services are due to close in the next few months (as my local one is), or have already closed, because of denial of funding.
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    United Kingdom: ME Association governance issues

    nope, you don't get to sneer about people being oversensitive if they disagree with you and then turn round and preach that "we must all come together".
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    Could there be an on/off switch for ME/CFS and if there is, what would that tell us??

    Or even on a smaller scale; it seems quite a common experience that trying a new medication causes a small improvement and then the problems come back. OK, placebo effect, regression to the mean, etc etc. But it would also be consistent with a feedback loop being temporarily disrupted and then...
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    Poll: To what extent are you (PwME) still shielding from Covid?

    The last time I was indoors with people other than family, which was months ago, I planned to wear a mask and had it in my pocket, but forgot to put it on (my brain was at capacity trying to stay conscious and occasionally talk). And of course no one else was wearing one so there was nothing to...
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    "The evidence for pill colour impacting placebo effects gets flimsier the more you examine it"

    Looking at the evidence for one of the things that tends to get quoted as a proven fact in discussions of placebo effect: "The BMJ tries to walk a middle ground. The review acknowledges that the evidence is inconsistent while still suggesting that colour might influence the effectiveness of a...
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    United Kingdom News (including UK wide, England, NI and Wales - see separate thread for news from Scotland)

    I've been listening to this in little chunks. Both interviewees talk about "recovery" but they agree "you never completely recover - you just learn that you have to manage your energy". Before illness LP describes herself as always busy and defining herself by productivity/achievement. So when...
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    What research do you want to see? (study ideas)

    Sorry - had a brainfade there.
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    What research do you want to see? (study ideas)

    NHS England month-by-month data for July 2021 to Feb 24 is here. https://www.england.nhs.uk/statistics/statistical-work-areas/covid-19-post-covid-assessment-service/
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