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You're right, I was writing too fast and wasn't thinking. So yes, when researchers are just looking at a new potential biomarker, like the nanoneedle test, it shouldn't be too hard to pop into the hospital and get some blood from patients, who probably already have a line set up in their arm...

I think that could provide some value if the questionnaire was thouroughly studied to not have many shortcomings. But I think hospitalized bedrest patients might be best. It's easy to find plenty of them - just look up "hospital" in the phone book. Maybe ask the nearest attending which patients...

Yes, what I've read is that curcumin by itself is almost completely destroyed by the digestive tract. Piperine from black pepper helps a bit. But there a various proprietary formulations that supercharge the bioavailability, many of which have been used in many studies assessing bioavailability...

I don't think whether they are healthy or not is important here if you also have a separate healthy control. The goal is to not only show that the marker shows different results from a healthy person, but that the level of exercise has nothing to do with the marker. As an example, given a study...

I think maybe step count could be a good proxy. Although that would add some complexity in the recruitment process. Maybe people diagnosed as severely depressed. Or maybe hospital patients on constant bedrest. But even if it's not perfectly defined between different researchers, I think even...

Well, I think it's important to include deconditioned and healthy. Because if it's just deconditioned vs. ME, then it's the opposite, and easy to say "it's because ME patients aren't actually sick."

I feel like as many trials as possible that compare ME/CFS to another group should include another deconditioned group, like sedentary depressed people. For example, I believe Ron Davis's nanoneedle test included healthy people and people with depression, though I don't know if they were...

I would assume it fundamentally doesn't change much. They whittle down both healthy and sick blood to smaller and smaller subsets of weight or type. Subsets which still have different effects on cells. Maybe they eventually see that the effect is still evident when both samples only have small...

I like this guy. Charismatic, humble, good at simplifying complicated subjects, and insists on listening to ME patients. Seems like a great advocate.

I've never heard of anything with stem cells + ME. Why is this a bad thing?

Agreed. Comparing the same patients before and after inducing PEM would not only ensure that every single participant actually has ME, but it would show if the ME biomarker is really a PEM marker. And I'd control with non-ME deconditioned people, like fatigued cancer patients, before and after...

The URL is messed up FYI.

Maybe it would help elucidate your model to study anecdotes of medication triggering ME/CFS, and seeing if the known drug pathways could potentially mesh with your theory in their effects on the immune or other body systems. For example, with me, marijuana and clozapine (dopamine antagonist)...

I haven't read more than the abstracts, but here are the two studies they reference: Use of symptom-guided physical activity and exercise rehabilitation for COVID-19 and other postviral conditions Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health...

I feel like I'm in wacky world reading this, knowing it's serious scientists in a serious journal. This seems like such an obvious attempt to cloak "PEM isn't real" in some sciencey words to make "you need to exercise" seem like a good conclusion. Like the logic seems to be completely missing...

It seems like he might use a modified Fukuda in his studies which requires PEM. This 2019 study from his lab says "participants with ME/CFS had to meet the following inclusion criteria: (i) age between 18–55 years; (ii) met Fukuda case definition criteria for ME/CFS (Fukuda et al., 1994)...

I added a page to MEpedia for Dextro-naltrexone, basically summarizing what he said in the video.

I haven't dug deeply into this, but might be relevant: Molecular mechanisms underpinning laser printer and photocopier induced symptoms, including chronic fatigue syndrome and respiratory tract hyperresponsiveness: pharmacological treatment with Cinnamon and Hydrogen, 2014 Worth noting that...

I couldn't really figure that out either, but you can press the applause button instead, for one idea per day. Not sure how it differs from an upvote.

https://blogs.bmj.com/bmj/2021/01/25/paul-garner-on-his-recovery-from-long-covid/ Oh wow. I'm almost certain this was a spontaneous recovery unrelated to the happy thoughts. It sounds a lot like some experiences in my own life. There have been times of severe depression/anxiety ebbing and...