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  1. Andy

    Intragenic DNA inversions expand bacterial coding capacity 2024 Bhatt et al

    Bacteria Flip Gene Segments to Alter Proteins Surprisingly Often, with Implications for Human Health "Proteins are vital to our bodies. They serve as structural building blocks for our tissues and organs and are responsible for their functioning in both health and disease. Genes, like recipes...
  2. Andy

    Intragenic DNA inversions expand bacterial coding capacity 2024 Bhatt et al

    Abstract Bacterial populations that originate from a single bacterium are not strictly clonal and often contain subgroups with distinct phenotypes1. Bacteria can generate heterogeneity through phase variation—a preprogrammed, reversible mechanism that alters gene expression levels across a...
  3. Andy

    George Monbiot on ME/CFS, PACE, BPS and Long Covid

    Lots of discussion about this here, United Kingdom: Science Media Centre (including Fiona Fox)
  4. Andy

    Sera from Rheumatoid Arthritis Patients Induce Oxidative Stress and Pro-Angiogenic and Profibrotic Phenotypes in Human Endothelial Cells 2024 Giordo+

    Abstract Background: Rheumatoid arthritis (RA) is a long-term autoimmune condition marked by persistent inflammation of the joints and various systemic complications, including endothelial dysfunction, atherosclerosis, and pulmonary fibrosis. Oxidative stress is a key contributor to the...
  5. Andy

    Gastrointestinal, Behaviour & Anxiety Outcomes in Autistic Children [in] Study of Synbiotics vs Synbiotics & Gut-Directed Hypnotherapy 2024 Mitchell+

    Full title: Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy Abstract Alterations of the microbiome-gut-brain (MGB) axis have been associated with autism spectrum...
  6. Andy

    Fluctuation of functional somatic disorders in a population-based cohort. The DanFunD study 2024 Schovsbo, Fink et al

    Abstract Background Evidence of incidence of functional somatic disorders (FSD) is hampered by unclear delimitations of the conditions and little is known about the possible interchangeability between syndromes. Further, knowledge on remission and persistence of FSD in the general population is...
  7. Andy

    Article: The early days of peer review: five insights from historic reports

    "The UK Royal Society has more experience of peer review than most publishers, with the practice used by its journals for nearly 200 years. Last month, the society unsealed more than 1,600 historic reports, dating from 1949 to 1954, and added them to its archive. The reports include assessments...
  8. Andy

    The Concept of ME/CFS

    Try this, any issues let me know.
  9. Andy

    Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue:... 2024 Ahn et al

    Claims to be about 'CFS', however "The inclusion criteria for this study were as follows: (1) agreed to participate in this study and provide written consent; (2) healthy men and women aged 30–59 years, with a score of 28 or higher on the fatigue severity scale (FSS)32,33 and a body mass index...
  10. Andy

    Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue:... 2024 Ahn et al

    Full title: Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial Abstract Background Chronic fatigue syndrome (CFS) reduces the health-related quality of life in the...
  11. Andy

    International: Science for ME social media posts

    Published papers thread for w/c 7th Oct. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid0yjPytFtduCpocsVuJHgxTBu59uZTh7CkwLmvT3RVkVeifR7RN4muYCEeDt4vngCcl Mastodon: https://med-mastodon.com/@s4me/113305069230318355 Bluesky...
  12. Andy

    Petition: S4ME 2023 - Cochrane: Withdraw the harmful 2019 Exercise therapy for CFS review

    Now at 12,088 signatures. Petition main page, https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review
  13. Andy

    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    Calls for Retraction of Absurd “Effort Preference” Claims from NIH Study https://virology.ws/2024/10/13/calls-for-retraction-of-absurd-effort-preference-claims-from-nih-study/
  14. Andy

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2024 and 2025

    From a post on Twitter, "I just found this! “The movement in 2024 of Chronic fatigue syndrome (CFS) to the Neurological disease category / Other neurological disorders subgroup (formerly in Musculoskeletal disease (general) category / Chronic pain syndromes subgroup)”"...
  15. Andy

    Trial Report Predictors of treatment response trajectories to cognitive behavioral therapy for chronic fatigue syndrome: A cohort study, 2024, Van Oudenhove

    Paywalled, so not possible to know how they defined "CFS". Also published in the good old Journal of Psychosomatic Research.
  16. Andy

    Brain hypoxia and metabolic crisis are common in patients with acute brain injury despite a normal intracranial pressure 2024 Lund et al

    Abstract Patients with acute brain injury are vulnerable to secondary deterioration, which may go undetected by traditional monitoring. However, multimodal neuromonitoring of brain tissue oxygen tension (PbtO2) and energy metabolism may be able to detect such episodes. We report a...
  17. Andy

    Review Systematic review and meta-analysis of standalone digital interventions for cognitive symptoms in people without dementia 2024 Cabreira, Stone, Carson

    Abstract Cognitive symptoms are prevalent across neuropsychiatric disorders, increase distress and impair quality of life. Self-guided digital interventions offer accessibility, scalability, and may overcome the research-to-practice treatment gap. Seventy-six trials with 5214 participants were...
  18. Andy

    International: Science for ME social media posts

    News in Brief posts for w/c 7th Oct. Twitter: Facebook: https://www.facebook.com/sci4me/posts/pfbid048J2pWLn9YhbZSA3iX8Q4DVN2uUsau3P2iCH2u9HcwhShMyAa1UP23NwYDEU3VtLl Mastodon: https://med-mastodon.com/@s4me/113299604994704177 Bluesky...
  19. Andy

    Review Functional neurological disorder in pregnancy, labour and the postpartum period: systematic review 2024 Cabreira, Carson, Stone et al

    Abstract Aims and method Functional neurological disorder (FND) most often presents in women of childbearing age, but little is known about its course and outcomes during pregnancy, labour and postpartum (the perinatal period). We searched MEDLINE, PsycInfo and Embase combining search terms for...
  20. Andy

    Review A review of intravenous immunoglobulin in the treatment of neuroimmune conditions, acute COVID-19 infection, and [LC]... 2024 Melamed et al

    Full title: A review of intravenous immunoglobulin in the treatment of neuroimmune conditions, acute COVID-19 infection, and post-acute sequelae of COVID-19 Syndrome Highlights IVIG has demonstrated efficacy in over 100 disorders, spanning hematologic, inflammatory, autoimmune, and infectious...
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