Bacteria Flip Gene Segments to Alter Proteins Surprisingly Often, with Implications for Human Health
"Proteins are vital to our bodies. They serve as structural building blocks for our tissues and organs and are responsible for their functioning in both health and disease. Genes, like recipes...
Abstract
Bacterial populations that originate from a single bacterium are not strictly clonal and often contain subgroups with distinct phenotypes1. Bacteria can generate heterogeneity through phase variation—a preprogrammed, reversible mechanism that alters gene expression levels across a...
Abstract
Background: Rheumatoid arthritis (RA) is a long-term autoimmune condition marked by persistent inflammation of the joints and various systemic complications, including endothelial dysfunction, atherosclerosis, and pulmonary fibrosis. Oxidative stress is a key contributor to the...
Full title: Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy
Abstract
Alterations of the microbiome-gut-brain (MGB) axis have been associated with autism spectrum...
Abstract
Background
Evidence of incidence of functional somatic disorders (FSD) is hampered by unclear delimitations of the conditions and little is known about the possible interchangeability between syndromes. Further, knowledge on remission and persistence of FSD in the general population is...
"The UK Royal Society has more experience of peer review than most publishers, with the practice used by its journals for nearly 200 years. Last month, the society unsealed more than 1,600 historic reports, dating from 1949 to 1954, and added them to its archive. The reports include assessments...
Claims to be about 'CFS', however
"The inclusion criteria for this study were as follows: (1) agreed to participate in this study and provide written consent; (2) healthy men and women aged 30–59 years, with a score of 28 or higher on the fatigue severity scale (FSS)32,33 and a body mass index...
Calls for Retraction of Absurd “Effort Preference” Claims from NIH Study
https://virology.ws/2024/10/13/calls-for-retraction-of-absurd-effort-preference-claims-from-nih-study/
From a post on Twitter,
"I just found this! “The movement in 2024 of Chronic fatigue syndrome (CFS) to the Neurological disease category / Other neurological disorders subgroup (formerly in Musculoskeletal disease (general) category / Chronic pain syndromes subgroup)”"...
Abstract
Patients with acute brain injury are vulnerable to secondary deterioration, which may go undetected by traditional monitoring. However, multimodal neuromonitoring of brain tissue oxygen tension (PbtO2) and energy metabolism may be able to detect such episodes. We report a...
Abstract
Cognitive symptoms are prevalent across neuropsychiatric disorders, increase distress and impair quality of life. Self-guided digital interventions offer accessibility, scalability, and may overcome the research-to-practice treatment gap. Seventy-six trials with 5214 participants were...
Abstract
Aims and method
Functional neurological disorder (FND) most often presents in women of childbearing age, but little is known about its course and outcomes during pregnancy, labour and postpartum (the perinatal period). We searched MEDLINE, PsycInfo and Embase combining search terms for...
Full title: A review of intravenous immunoglobulin in the treatment of neuroimmune conditions, acute COVID-19 infection, and post-acute sequelae of COVID-19 Syndrome
Highlights
IVIG has demonstrated efficacy in over 100 disorders, spanning hematologic, inflammatory, autoimmune, and infectious...
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