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Thanks for all the replies. The main comment seems to me that, while the protocol clearly has an effect on (most0 patients, as well as biological effects, there are doubts as to whether this amounts to full post-exertions malaise. That view is reinforced by the two people to have undergone the...

Sorry. The Stanford video is best https://www.s4me.info/threads/cfs-research-center-at-stanford-second-annual-community-symposium-sept-29-2018.3255/page-5#post-109963 @ 2:26 He did, and he made a case for several: for example, mental fatigue could be explained by one of the micro RNA...

Dr Alan Moreau presented preliminary results of his work on micro-RNAs (miRNA) at the recent Stanford (2:26) and CMRC conferences. Micro-RNAs are small molecules that regulate gene expression by binding to messenger RNA and blocking their translation into proteins. miRNAs might be new to you and...

Mostly, Michael Sikora recapped last year's finding of T cell clonal expansion in ME/CFS patients. But I liked that he made a real effort to make his talk accessible to a wider audience, and maybe it will be useful to those who want to know more about the role of T cells in the immune system...

Persistent fatigue as a model for CFS Sorry about the length of this: would have been shorter if I'd had more energy Concerns about this research have already been covered well: Pariente's strong belief that ME/CFS is a psychosocial illness; that this isn't a study of ME/CFS itself, but a...

My notes on the presentation from Dr Jarred Younger (@5h 27’): A new, simpler way to measure neuroinflammation Younger presented findings from his study in which he used brain scans to reveal levels of metabolites and changes in temperature across the brain. He proposed that these measures are...

In principle, this strikes me as a very good idea. thank you, Graham and @Barry . The current problem is that, while there are exciting findings, they haven’t been Published and/or replicated and/or are in small studies. I suspect that this rules out and Horizon-style program. I would feel...

By my calculation it’s 10 patients x three centres x 2 years equals = 60 patients, plus the same number of controls. That is a very small sample, but remember they are using a before/after exercise approach and that gives much “cleaner“ results, as explained here: ( from a statistical...

I know that quite a lot of people are desperate for progress and while there are no clear candidates right now, things really are visibly moving on. The field is much stronger than even five years ago. This is all the more remarkable given that this has been done on a shoestring - relative to...

A brightening future: the state of ME/CFS research - ME/CFS Research Review Although there are no treatments for ME/CFS on the horizon, things are looking up thanks to recent findings and a substantial increase in the amount of high-quality research. The field still needs much more...

if I have the energy, I would. I don’t :(. My probably-final blog has been stuck in the pipeline for a month as I dxon’t have the energy to produce even a fairly short one. It’s worth noting that Maureen Hanson’s collaborative is going to do a fairly large replication (50 cases/50 controls, I...

From Cort’s blog: "Because Younger didn’t know exactly where in the brain to search in ME/CFS, that technique wouldn’t work for him. He had to develop a method that would produce a heat map and a chemical signature of the entire brain, and found a Florida researcher who developed a way to do...

I don’t know, but why not suggest it? It sounds like a great idea.

The fabulous Julie Rehmeyer, I presume? Welcome to the forum, @Jrehmeyer You asked a good question. The short answer is that biological systems are complicated with lots of things interacting with each other. So just as symptoms are common to many illnesses, some biological findings will also...

Diagnostic tests First 20 minutes of video are about their new diagnostic technologies. My notes, FWIW: Biomarker: the primary concern is to demonstrate that patients are sick, rather than finding differences with other diseases. Nanoneedle chip: uses a single drop of blood (red blood cells...

I don’t know if this, from the blog, is relevant: "Another of the Neale results is that women that have G at this position tend to have very slightly lower lymphocyte count (rs7337312; p = 4.6×10-7; other variants in LD have p < 5×10-8)." they recruited people aged 40 to 69 to increase the...

New blog at ME/CFS Research Review Guest blog by Professor Chris Ponting and colleagues. Summary A new analysis using data from UK Biobank indicates that one version of a particular gene increases the risk of ME/CFS in women. The gene codes for a transporter protein in the mitochondrial...

Spot on. My quoted blog’s opening line did make clear patients’ simple motivation: “Like all patients, what I want most from clinical research is treatments that work, not ones that merely look good on paper."...

The state of my health has spiralled downwards this year and is now dire, so this will be the last major blog from me for the forseeable future. If my energy levels improve, I might in future be able to write some shorter blogs on simpler subjects, which might be a relief for everyone. There...

I'm sure cost is a big factor: the metabolomics analysis in particular is very expensive. Although they have 100/100 patients/controls in the full sample, only 50/50 are definitely included in the exercise study, though Ian Lipkin said they hope to expand that to 75/75. All 100/100 will do the...