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Also, it looks like one patient in this small study got status epilepticus in the 20 mg group. Not saying this is causally related but it should be noted. https://www.europeanpharmaceuticalreview.com/news/164740/iv-suramin-may-be-a-promising-autism-treatment-shows-phase-ii-study/

So it seems that the Phase II trial in South Africa did not replicate Naviaux’s original finding of 20 mg being more effective than placebo. He had 5 patients per arm in the original trial if I recall. In this new trial, 10 mg appeared to be more effective in that it seemed to separate from...

Treatment of simple phobia is the only area where I would concede that efficacy of CBT over doing nothing has been demonstrated. However, this is the easiest psychiatric disorder to treat, low hanging fruit. Evidence is a lot muddier for more complex anxiety disorders like panic with...

Good to see this sort of material out there. The exercise lobby is so strong despite no evidence of benefit for weight loss or other outcomes.

Netflix is hit and miss and has much lower credibility than BBC but it’s better than nothing. Netflix recently made a documentary about CRPS, another contested illness considered functional by some, and it was heavily biased in favour of the family and against the mainstream physicians involved...

Interesting background. I didn't know that BBC commissioned a statistician to review PACE. Without knowing more details about the statistician's report, it's difficult to judge its scope or accuracy. As someone who was closely involved in the statistical reanalysis of PACE FOIA dataset, I can...

It’s quite funny actually seeing people who abused and derided us all their lives get felled by basically the same condition.

This infamous study should send a chill down anyone’s spine. Despite clear evidence of organic disease and a fatal outcome, they still would not admit that they were wrong about FND. I hear this a lot anecdotally as well. Cases where someone was told they had FND, then a real diagnosis is made...

We can expect to see quite a bit of this scrambling to reposition now that updated technologies like 7 tesla MRI scanners are becoming available. Any new diagnostic procedure in neurology puts a lot of psychobabble careers at risk.

You have got to be kidding me. What medical records did they keep in Malawi in 1900?

The problem with this is that it’s obviously moving the goalposts. CBT for nonepileptic seizures is billed as curative, not supportive, just like CBT for ME/CFS. When CODES showed that CBT doesn’t work, the redefined the goal of treatment as supportive/palliative. Ok so you still have...

I was dreading what this would be about after reading the title but then it turned out to be a surprise.

Yep. But recruiting sick controls who are as inactive as us is very challenging. I don’t know anyone who moves as little as me. Even people with cancer seem more active than me.

This looks quite useful. Wouldn’t really regard it as psychosomatic research.

Another hyped paper bites the dust.

We have every reason to be super cautious. Have the genetic association studies (eg polygenic risk scores) in psychiatry led to a reduction in stigmatisation/abuse of patients with schizophrenia, depression etc? Nope, not in the slightest. There's no clear pathway from finding a genetic...

Syncopal episodes can cause weird movements and get misdiagnosed as nonepileptic seizures. The symptoms of POTS wax and wane and affect mostly young women. Fertile ground for FND demagoguery/abuse.

Psychiatric disorders also have genetic associations.

I thought this had failed replication. Now they’re jumping from mice to interventional human trials?

Chat bot I take it.