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"...ion handling..." A potential channelopathy reference again? Are we talking channelopathies as downstream effects, and abnormal RBC deformability simply further downstream? I know - way too speculative. Also, I always thought of channelopathies as the starting point, ie, genetic, usually...

Our's would be an acquired altered RBC deformability, if applicable - I think (it could be genetic, but adult onset in some and childhood onset in others makes that proposition seem less likely). This paper addresses hereditary hemolytic anemia. What about acquired hemolytic anemia, or...

This paper specifies skeletal muscle. Maybe the Australians were on to something with the calcium channelopathy theory. But the tie to EV escapes me. Are EVs remnants or blebs from skeletal muscle cells?

Not unlike the logic underpinning MS, truth be told.

Well, not obvious to everyone.

One of the authors is named Fukuda? Oh, sweet irony....

Very cool, in a not-cool-sort of way. I don't think they found a new tick. I think they found a species of babesia not normally found in Scotland. And one never found in sheep before, which is somewhat alarming. The article says the chances of contracting this form of babesia are remote. It was...

It is frightening just how many swaths of medicine not merely come up short, but suck. This is not what we were taught in the 60's and 70's and 80's - although we did start to learn in the 80's that dark, unexpected things lurked despite earlier medical posturing.

How to fail a given drug for a disease: trial it at insufficient dosages for too short a time frame. I wonder, though, what they imagine they are shotgunning mino at. All that voodoo entangled Tau Rastafarian biofilm Zen Protein comprised of...what? You know who got real good with this version...

Probably true, and I certainly enjoy reading that perspective. A corollary might be that suffering from a chronic disease is an exercise in learning that the medical community probably has no idea what they are on about - learning how doctors and researchers get things wrong. I mean no...

Clinicians and researchers tend to share the human trait of not seeing what they don't want to see. The NIH seems to enjoy an inexhaustible supply of this trait.

"Therefore our results represent a step forward for personality neuroscience within the study of biochemical systems and brain structures." Bets?

This phenomenon is not just restricted to HIV.

I'm glad I misunderstood, but not surprised; I'm almost getting used to misreading and mis-writing. Not quite, though.:unsure:

It is frustrating to the nth degree. :(

Yes, it is, but not as bad as it used to be. Still treated as such, though. But adding PEM to the mix helps enormously. I think this is incorrect in that it specifies a condition has to be epidemic. I can match ME with a different encephalomyelitis that does not manifest in epidemics. The...

Right. The take away is that in the US, EIS people - or later their CDC superiors - replaced ME with CFS. CFS WAS more vague, but that doesn't mean ME wasn't folded into it. Yet by default, most US victims had only a CFS diagnosis to cling to, and accordingly sometimes earned the disdain of...

It's a non sequitur to suggest that a belief that ME/CFS is not a disease, coupled with a belief that ME/CFS patients can enjoy improvements after medication that last for years, but due solely to the placebo effect, might present potential problems? If so, I'm guilty. But you've managed to not...

We couldn't agree more here. Again agreed. No. That is inference, and it belongs imo more in the psych community than a discussion of ME/CFS as an organic disease. This theory, this line of thinking, leads over a cliff. You couple that with your stated inclination that ME/CFS is NOT a disease...

Well, in your capacity as a medical doctor, do you know of any diseases that have a history of a swathe of patients with remissions/improvements that last for years attributed to the placebo effect? Is there reasonable precedent here?