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  1. Trish

    Depression is the most significant independent predictor of fatigue in patients with primary Sjögren’s syndrome 2023 Ayar et al

    Since this study was done at a single time point, any causal attribution of one symptom predicting another is clearly not possible. I remember querying the use of the term predictor on a thread for another paper of similar ilk and being told in this context the word predictor simply means if...
  2. Trish

    Excess mortality in England post Covid-19 pandemic: implications for secondary prevention

    At a quick glance they don't look like the kind of meds that can be over the counter. One of them is given through a drip, and they all have side effects and contraindications. And are probably very expensive.
  3. Trish

    Clare Gerada: influence on UK medical practice and ME/CFS management

    I hadn't realised CG started her medical career as a psychiatrist before switching to being a GP.
  4. Trish

    The Observer/Guardian article: Does the microbiome hold the key to chronic fatigue? About patient led 'research' group Remission Biome.

    I don't think there's any justification for a clinical trial for any antibiotic for ME/CFS. Antibiotics are over used already, and should be used only for bacterial infections. They don't seem to be considering in their interpretation of their 'remissions' that many pwME report a temporary...
  5. Trish

    United Kingdom: ME Association news

    The MEA survey this month is on alcohol intolerance and ME/CFS or LC. https://meassociation.org.uk/me-association-survey-alcohol-intolerance/
  6. Trish

    United Kingdom: ME Association news

    The ME Association and ME Research UK announce funding for a study that aims to create a diagnostic test for ME/CFS See this thread: https://www.s4me.info/threads/the-n...ned-on-the-lab-bench.34019/page-4#post-501131
  7. Trish

    United Kingdom: ME Research UK (MERUK) News

    The ME Association and ME Research UK announce funding for a study that aims to create a diagnostic test for ME/CFS See this thread: https://www.s4me.info/threads/the-nanoneedle-salt-stress-test-%E2%80%93-too-good-a-clue-to-leave-abandoned-on-the-lab-bench.34019/page-4#post-501131
  8. Trish

    Maeve Boothby O'Neill - articles about her life, death and inquest

    For more personal thoughts there is also this In Memory thread in the members only area Maeve O'Neill
  9. Trish

    Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in ME/CFS 2023, Kavyani et al

    Thanks for replying @DMissa. No problem. I don't have the energy or knowledge to look at the detail either, so I'll leave it to others to discuss.
  10. Trish

    True prevalence of long-COVID in a nationwide, population cohort study, 2023, Pell et al

    All this shows is counting symptoms is not a helpful or valid way of assessing whether someone has long covid. Surely they should realise by now that this has to be combined with a measure of severity and frequency of the symptoms and impact on ability to function.
  11. Trish

    A cognitive behavioural group treatment for somatic symptom disorder: a pilot study 2023 Jongsma et al

    So basically they cherry picked a few results with small effect sizes and most of their questionnaires didn't given significant results. The conclusion should clearly be to scrap this treatment as a bad idea and move on. Instead the oh so predictable conclusion of 'potential effectiveness' and...
  12. Trish

    Is ME more heritable on the mother's side?

    In my family those I'm aware of are possibly my father, definitely myself and my daughter, and now my niece (sister's daughter) has long covid. [I say possibly about my father because he had what was described as a recurring virus by our GP, that started in the 1930's when he was in his 20's...
  13. Trish

    Open Medicine Foundation (OMF)

    Some posts have been moved to: The LIFT trial (OMF) - Pyridostigmine (mestinon) and Low Dose Naltrexone (LDN)
  14. Trish

    UK Dorset ME/CFS clinics

    Thank you for sharing your experience, @chillier. I'm sorry to hear you were harmed. I think they need to be told about this. They need to understand the harm they are causing with this approach.
  15. Trish

    UK: NHS RUH - Bath Centre for Fatigue

    No, I have written about the Dorset service as I experienced it over 10 years ago. https://www.s4me.info/threads/uk-dorset-me-cfs-clinics.32157/ Edit: Replies moved to the Dorset thread
  16. Trish

    UK: NHS RUH - Bath Centre for Fatigue

    It looks like a service run by occupational therapists. I don't understand the section on a private service. Does this mean it's run separately from the main NHS service and people have to pay, or that it's NHS work outsourced to a private company. I'm very suspicious of a service that groups...
  17. Trish

    Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in ME/CFS 2023, Kavyani et al

    Thanks @DMissa for explaining the background to the research. It's really helpful to see it in context. I'm sure it's frustrating for authors for their work to be paywalled, though I guess people working in universities don't notice the problem so much as their universities pay for access to...
  18. Trish

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2023 (including government plans to scrap the work capability assessment)

    Given that there may be a change of government before that, I would not make any assumptions about what happens in 2025
  19. Trish

    Outcomes of a fatigue management intervention for people with post COVID-19 condition 2023 Tadhg et al

    From reading the abstract it looks like the usual unblinded, no control group, subjective outcome measures nonsense. And the abstract doesn't say what the intervention involves. So it tells us nothing. Also the entry criteria was at least 12 weeks symptoms, so most would probably have recovered...
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