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Sorry, I was mixing up my threads! Will delete my original post.

A key part of an ME/CFS diagnosis is that symptoms are not due to other causes. In the case of long covid, other causes seem very possible - regardless of matching ME/CFS symptoms. Many people in the ME/CFS field believe that some long covid is indeed ME/CFS, but that most cases are not. If we...

Lead-author replies to questions raised here about the study - cont... More detail 1. Could you comment on the apparently-odd fatigue scores? The lowest patient fatigue scores were very low (0 pre-test, 10 post-test) and the highest control score was very high (70 pre and post-test). These...

Answers from lead author Dr Inigo Murga to questions posed on this thread My thanks to Dr Murga for replying to questions I passed on. I don't have permission to share his email and so will summarise his points. Highlights The apparently-odd fatigue scores were accounted for by just a few...

The discussion (and voting) of and on possible images came up with a final selection of photos that we think are a worthwhile improvement on current media images showing the likes of yawning well-groomed office workers to represent ME. We now have a final selection of photos we think are a...

Good point, I will ask the researchers about this too. Though people who wind up in research studies tend to be hyper-educated (lest we ever think they are really random samples).

This study found a huge difference between patients and controls on a relevant measure People have made a lot of valid points about how difficult it is to produce a "fair" test of cognitive function in people with ME, including issues around time-of-day and state of health, and the best way best...

If we got to choose, I doubt that any of us who voted 'yes' would choose every photo. It's about being pragmatic, sadly. A stopgap until we have something better. This is a real problem. The key consideration is that a picture is worth a thousand words. A photo showing someone not obviously...

We need your opinion on this pool of photos: > Proposed collection of ME/CFS images for use by the media < A group of forum members suggested and selected (here) the photos - as a resource for people who choose the images for stories in the media about ME. Everyone is fed up with the media...

I find it hard to imagine that they had done this but failed to mention it in the paper ;-). Perhaps I will simply ask if they plan to do this (or plan to test a significant number of ME patients who are not on medication.) good point.

If replicated, these findings are of huge importance, IMO. Over 80% of people with ME report cognitive issues yet research studies have never found very much (including the Cognitive Function Montreal test reported here). The biggest effect has been for reaction speed — and I've never heard...

Veronica, who is quite ill, asked me to post this.

My estimate: 80k cases of LC in the UK that might be ME/CFS. Comments on my assumptions are welcome.

Poll: what do you think of these possible images for a photo collection? VOTE! This thread has been discussing a possible collection of photos from the Getty Images photo library that is used by many media outlets. The thread largely reached a consensus but there was some debate about some...

Two more published poems from Veronica draw on her experience with severe ME. https://www.abilitymaine.org/bs2021fall/%22leo%E2%80%99s-bite%22-and-%22roar%22

I have lost touch with Omf research and with this specific research. But my impression, which may be wrong, is that the metabolic trap is a main focus if not the main focus at Stanford. And that OMF brings in $5 million a year. I don’t understand how that squares with somebody working part time...

There is a member-only thread looking for feedback on a selection of possible stock photo library images (and asking for better suggestions). What do you think of these photos to depict PwME in the media? Help us build a collection!

Jam tomorrow, and important general points Promising areas but no firm results yet... The importance of cell subtypes and subgroups Unutmuz stressed the importance of looking in detail at different immune types and subtypes, particularly for T cells. Nath found mitochondrial deficits looking...

not exactly. Many changes will be synonyms (changes in DNA sequence that either lead to the same amino acid being specified) or a similar one in non-critical parts of the protein. RARE variants won't necessarily be complete loss of function, but they are likely to have a significant loss of...

my understanding is that rare variants almost always occur in the coding region (i.e. affecting the protein that is made, not the quantity of the protein). This is because such protein-coding variants often have large effects. Most variants that turn up in GWAS are in non-coding regions and have...