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@Michiel Tack That was a truly brilliant blog: a beautiful assembly of strong evidence against the use of non-blinded trials with subjective outcomes, and a great story about Louis XVI. Just one thing: please don't blog about biomedical research, else I'm out of a job.

My energy is very limited, but I would be willing to help if I can. I think the core principle needs to be something like “basing policy on the best available science, recognising the limitations of the current science research and avoiding claims that to go beyond what the evidence will...

Comments on the paper (Part 1) Overall, the paper looks quite solid, with many different approaches used to reach findings that fit together into a plausible model. Note that the paper is a pre-print, which means it hasn’t been reviewed. It is increasingly common for scientists to first...

Only a day to read the paper? Good going. I've now watched the video and taken a look at the paper - and will try to explain, starting with my attempt to explain what mitochondria do, to tee up the paper. Much of this will probably be way too basic for many people here but I usually find it...

My updated take on the Stanford symposium, With thanks to you @Michiel Tack For a great detailed summary and tweets and @Ben H (and Cort) for tweets

I was only able to follow the symposium on Twitter and this is how it looked from there. How did it look to those who saw more of it than me? Overall, I was disappointed by the lack of progress (hey, what's new: this is ME/CFS). In particular, there has been no progress on either the metabolic...

The results are certainly eye-catching. I've not yet read the full paper (and am hoping to avoid having to) . I wonder if those good people who made the effort could answer a few questions. 1. How do the Seahorse results from this study fit in with previous Seahorse results? I am aware that...

Thanks to you and your fellow advocates for all that you have done, and achieved. Please do, and thank you!

Launch of Canadian research network makes a big statement about ME The Canadian government has announced a modest $1.4 million investment in a new research network and delivered a big message: ME is a serious illness, deserves respect ("Let's remove the insult from this injury") and needs more...

Good to see this published. Case reports are a very low grade evidence, so the key point from the Workwell tweet is "now to get funding and test with larger numbers."

I’ve shared the MillionsMissing Canada FB post about this on my Facebook page, and included a commentary. I would be hugely grateful to anyone who can check that I have the details right. I’ve tried to include some of the amazing things shared on this thread. Ideally, I’d write a blog, but I’m...

Objective measures of post exertional malaise Just wanted to highlight the idea submitted by the famous anonymous author: The other idea is something that came from a 'citizen scientist' patient. The key clinical problem in ME/CFS is exertion intolerance. I think we need to be able to measure...

I have now read the Tomas paper and the Myhill/McLaren Howard response, and think it would help to focus on some of the detail. Overall, the findings in the new paper appear to be pretty good evidence that the MES test isn't reliable, because it can't separate patients and controls. However...

This strikes me as a big step forward for the field. I remember reading the original paper and feeling that the results looked almost too good to be true. But the acid test is always a replication attempt, ideally by an independent group and that’s exactly what’s happened here. An independent...

Update [to blog]: Eric Lander highlighted further GWAS successes at a recent lecture at the Broad Institute (which is based at Harvard and MIT). Heart disease. Analysis of significant SNPs revealed that HDL-cholesterol is not protective (which explains why the $5 billion investment by the...

Thanks,@Woolie, lots of good points there and I now know quite a lot more about anorexia nervosa. There are indeed several possible ways in which the association with metabolic and related factors SNPs can be explained non-accordingly. But also no clear evidence that they can't play the...

Thanks, @Woolie, and I also thought it was interesting about the value of GWAS I think we might be slightly misunderstanding each other so let me start by summarising what I understand from what you said: 1. Anorexia nervosa is primarily an OCD-type of behaviour. 2. The link with...

Worth reading the study mentioned in the tweet: it relies on demographic data to reidentify people. there was nothing in the PACE trial dataset that would help anyone, at least not as far as I can tell from the article. I suspect that Michael Sharpe hasn't read it.

You have. Interestingly, there was no correlation between anorexia nervosa and SNPs associated with IQ. From the evidence presented we can't tell, but my reading is that it is more likely than unlikely — and further analysis (and research!) could sort this out. Diagnosed cases of anorexia...

That’s very interesting and I wonder if they had any more success treating AN in the past. I also tought that @Woolie made a good point in reply: "What's changed since 1960 is the high social desirability of female thinness, I'd expect that nowadays, there'd be proportionally more cases where...