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I agree, and that's why I was joining the discussion GWAS are good at providing causal evidence. If there is a link to anxiety-related genes, or other relevant jeans – even if subthreshold in. DecodeME – that coup support the BPS claim to a degree. They've always accepted that they are...

Sorry, I see what you mean. I'm not sure what case BPS proponents would make, so this feels like shadow boxing. And I don't think we can award the non-BPS view a knockout win without knowing BPS arguments. I expect that, at least, they would argue for the 'success' of CBT (which takes us back to...

? I'm not sure what you said, I was responding to Robert.. But is surely depends on the results. If anxiety-related genes show up in DecodeME, or at least are prominent if not significant at the threshold, wouldn't that make it hard to rule out a role for them? (I don't know what the results...

I think it might be quite difficult to prove that there isn't a substantial role for the mind. My reading of CBT in particular is that it's built on the idea of anxiety about symptoms. So you might expect to see anxiety-related genes in a GWAS. Possibly, you would expect to see such things as...

I think that's the most important point. Based on the discussion here, it's still not clear what the best way is to respond , or how best to present an argument. I am very wary of the risk going down mind/body rabbit holes. I think we can be sure that those wedded to a psychosocial...

I'm sure that's the journal, so that must be it, thanks.

I suspect this has been covered before, but I'm looking for a paper/journal piece penned by SW, possibly in 1999 (maybe later). In it, IIRC, he reflects on how the BPS model has held up and concludes, 'pretty well', though he concedes that his original suggestion that CFS was a form of...

Abstract: >We applied this method to a very homogeneous sample of patients belonging to a unique and clinically well-characterized multigenerational pedigree with one of the most severe forms of early onset AD, carrying the PSEN1 p.Glu280Ala mutation (often referred to as E280A mutation), which...

I will be interested to see how this holds up in DecodeME. With only 77 cases, the WES looks underpowered to me.

An SF 36 physical function of under 30 is lower than usual in clinical cohorts, I think. IIRC, the pace trial was mid 30s. Similarly, 97.5 is above average for the population. Maybe that's because it's specifically healthy controls, but it looks like there's been no attempt to control for...

I think that's the key point: we need replication. These are all interesting findings. But there are hundreds, if not thousands, of interesting findings out there. Almost none of them have been replicated, so we can't rely on them. What we need are more independent replications, like this...

Maybe it's that, I think I've seen a presentation suggesting the trials would be underway by now. I thought I'd also read that they had sorted the genetic test they need to identify sub groups protesting. But I haven't seen any confirmation that those trials are in progress – that was an...

I find that surprising, even though the combinatorial method, in theory, is able to find true results from much smaller samples. The big problem I see in saying that a gene or genes explains the symptom of any subgroup is that these are SNPs. Snips are common variants , which indicates they...

I don't know how significant this is. I quite often don't have symptoms at rest, but I always have the problem of minimal exertion exhausting me. In other words, if the problem was that something in my blood was stopping my mitochondria working properly, I would've expected that something in the...

I didn't hear the talk, but understand that she and @chillier attempted to replicate the most robust/replicable 'something in the blood' finding, and could not Negative replication results are so important because they stop the field from having endless possible theories. Culling things that...

As we have year of onset, we could look at 2009/10 in isolation.

Thanks for bearing with me, @Jonathan Edwards. My brain is in slightly bit of shape this evening, so I’ll try one more post. my brain is doing better this evening, so I’ll try again in response to your points. First of all, it would be wonderful if everything amounts to signalling issues –...

Yes and no - for me at least pain and fatigue and not the only thing that limit our ability. This goes to the heart of psychosocial and biopsychosocial views of the world and what we need to do to recover, at least as I understand them. I hope I make more sense below: Pain and fatigue exist...

Thanks. That’s possible, though the participation rate was lower than for the Nordic countries, and my understanding is that The survey was promoted by the main ME organisation. I’m guessing If this happened, we might see it in the age survey, Which we will look at, as above.

Good question – we have the information and will check ( from memory, countries were pretty similar, but my memory isn’t so good).