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And this fluctuation in activity , with PEM kicking in then not through conscious choice, would have been good data. If it was simple choice without physical consequence then there would be no significant fluctuation in activity levels.

I have nit read the paper so this may be bullshit, but if these people still had cancer why would they not be fatigued. Cancer highjacks metabolic processes ( there are striking similarities to glucose mechanisms with some pwme) , immune processes etc - if these do not return fully to normal (...

Can someone tweet this kind of thing? I am crap at at Twitter, but wider awareness of this kind of statement can only be a good thing.

From the other place - a few threads AMPK in blood cell deformity http://forums.phoenixrising.me/index.php?threads/omfsciencewednesdays-red-blood-cell-deformability-in-me-cfs.58380/page-2#post-966242 AMPK role in M3 signalling...

AMPK is also involved in " clock" processes, and could be significant in Naviaux's hypometabolic state hypothesis....

This kind of article is excellent.

Interesting- potential upstream modulation paths mentioned ( including liver which has always been my hunch as part of the issue with my aunt and daughter). There were a few very interesting threads involving AMPK' s potential role in the other place.

@Gingergrrl . I think it is likely that there are others who will present similar to yourself. The difference may be access to testing and talking to someone who has even a bit if a clue. Here in the UK it is difficult to even get a full thyroid panel done on NHS, let alone anything more...

Yes, keto can be evangelical in its enthusiasm. I found the video good for explaining mechanisms. Whilst cutting down on carbs has helped a bit- with something as complex as metabolism, and a broken metabolism at that, keto does not work for us. Low base thyroid/ adrenal hormones seem to...

The need is to get things into wider awareness. We ate great sounding boards, but unless we find a means to disseminate an argument/ convey experiences to a wider audience , nothing changes. I can appreciate that for many there can be serious consequences, and therefore the " don' t rock the...

Better get my tin foil hat out if the cupboard

https://www.frontiersin.org/articles/10.3389/fendo.2017.00045/full Leptin resistance, white and brown fat signalling - one underpinning mechanism of obesity. Podcast on adipose and insulin resistance easier to understand . Food for thought

Check out TOFI - thin on outside, fat on inside - there are indications that there are rather a lot of people in this category. All calories are not equal, the body uses the different macronutrients in different ways. I will try and find info on the leptin ghrelin mechanism and it seems to play...

I read somewhere a couple of years ago that ifsignalling is broken and the leptin/ grehlin mechanism is affected then it doesn't seem to matter how little calories you eat , some of it will be shunted to fat. The normal feedback loop has gone .

You can have little body fat and still have insulin resistance. Insulin resistance plays a role in many conditions .Adipose signalling plays a key role https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640267/

Read the suggested meals and perhaps you will see why we have problems https://www.google.co.uk/amp/s/www.diabetes.org.uk/diabetes-the-basics/food-and-diabetes/i-have-type-2-diabetes%3famp My cousin with cancer had a similar high carb diet recommended - for acdisease that proliferates by...

It dosn' t mean they are not active. Look at how media reporting is dealing with Brexit- there have been many public demonstrations in the past few months - not seen much in the mainstream media about them though....

Using a cut off of 24 hours to try and characterize PEM has flaws too. It' s 48 hours for my daughter for full kick in

@Tom Kindlon @Carolyn Wilshire comments on social media would be appreciated. this is the kind of info that misinforms paediatricians and clinicians.

Makes NICE' s failure to remove these treatments more damning.