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  1. Jonathan Edwards

    Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping, 2021, Castro-Marrero et al

    I cannot work out what Prusty's slide is supposed to indicate.It doesn't seem to have anything to do with high C1q levels. C1q contributes to formation of C1 complex, not the other way round.
  2. Jonathan Edwards

    Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping, 2021, Castro-Marrero et al

    The key question would be why a difference inC1q has not been picked up before. It is not measured routinely in the UK but probably would be in the US. I have not looked through the whole paper but I don't know if it gives a trawl of previous studies of C1q. Sorensen and colleagues did detailed...
  3. Jonathan Edwards

    Havana Syndrome: U.S. and Canadian diplomats targeted with possible weapon causing brain injury and neurological symptoms

    No it is nonsense - at least in the sense that it is as implausible as saying that when you look at a red rose a bit of your brain turns red. There is an old saying. Keep an open mind but not so open that your brain falls out!
  4. Jonathan Edwards

    Havana Syndrome: U.S. and Canadian diplomats targeted with possible weapon causing brain injury and neurological symptoms

    The stuff about microwaves and brains looks like straightforward nutcase pseudoscience to me. If it had any basis it would have been well documented decades ago. The idea of microwaves interacting with brain tissue to make' sounds' is plain nonsense.
  5. Jonathan Edwards

    Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2021, Lutz et al

    Interesting that you found that. Going through the thread I was just about to remark that MBL is generally thought of as protector against extracellular toxin producing bacteria like staph aureus and if anything might be a bad thing when it comes to intracellular pathogens. If pathogens have...
  6. Jonathan Edwards

    Frequent IgG subclass and mannose binding lectin deficiency in patients with CFS, 2015, Guenther, Scheibenbogen et al

    The first author works in an immunology department where people with things like MBL deficiency probably turn up more often. Ditto subclass deficiencies.
  7. Jonathan Edwards

    Will it ever be reasonably safe for PwME to go back into society, post-Covid?

    That seems unlikely. We are just beginning to get to a state of herd immunity with 80% of adults vaccinated. The fact that the numbers of cases are flat despite hardly any restriction suggests that it is working, even with delta.
  8. Jonathan Edwards

    I AM MADELINE podcast series

    What is the reference to a treatment that works about?
  9. Jonathan Edwards

    Will it ever be reasonably safe for PwME to go back into society, post-Covid?

    I think if headline case numbers fall to 1,000 per day risk will be pretty small. There are lots of hidden factors that make the headline figures on their own misleading. I think risk now is much small even with figures still high. Certain sections of the community tend to mediate spread at any...
  10. Jonathan Edwards

    Will it ever be reasonably safe for PwME to go back into society, post-Covid?

    Covid-19 will fade into the background and become a minimal risk. We are not beyond the point of being able to eradicate Covid19. We haven't got near that yet. Having not done what New Zealand did it was bound to take 2-4 years to get enough people immune for the virus to stop spreading. Our...
  11. Jonathan Edwards

    Physiotherapy for functional motor disorders: a consensus recommendation, 2015, Nielsen et al

    We recommend that physiotherapy treatment is based on a biopsychosocial aetiological framework. This is just bad medicine. In modern medicine we do not base treatment on theoretical frameworks. We base it on evidence of safety and efficacy. It is salutary to compare this statement with what is...
  12. Jonathan Edwards

    UK Action for ME - policies, actions and publications - discussion thread

    Well, if the majority of blokes are women that sounds like real diversity;)
  13. Jonathan Edwards

    GAS (Goal Attainment Scaling in Rehabilitation), GAS-light, and gaslighting.

    Are you sure about that David? Did it arise and then disappear? And then arise again? Was it just that you thought it arose out of the film or were persuaded that it arose? Did it sort of flicker in and out of a sort of Wicki consciousness? Was it just a dream you wanted to tell me about seated...
  14. Jonathan Edwards

    GAS (Goal Attainment Scaling in Rehabilitation), GAS-light, and gaslighting.

    Quite so. It probably takes the Homo sapiens at least a decade to derive a gerund from a noun.
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