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This reads like someone who has read an immunology textbook but not understood it. I may be getting old but in the days when I was in immunology an abstract like this would get a straight rejection. The sentences aren't even in a sensible order. 'monocytes were sorted from PASC patients using...

This is not the meaning of fatigue relevant to ME and I doubt you would get many doctors to agree that it is relevant.

Hydrostatic pressure in relaxed muscle should be slightly below atmospheric. That suggests to me that the pressures here are indications of muscle contraction. It would not be surprising if people with a diagnosis of fibromyalgia contracted the trapezius harder when a needle was stuck in.

It looks like the second references really Saffron and Pheby, 2009? It may be good paper but the quote is a bit confusing.

I not that the opening blurb refers to paper by Alison Wearden and Caroline Chew-Graham. It goes on to cite: Without a diagnosis, patients can experience more severe symptoms and develop unhelpful illness beliefs or management styles, which then become entrenched making any subsequent treatment...

I get the strong impression that therapists just find it too hard to let go of the idea that they know what to advise - when nobody does. As far as I can see all that needs to be said to patients is: 1. Exercise is not going to make you better and may make you worse. 2. Once you ARE better...

It may be. But did they tell the patients that it was? Or did they assume the patients had read Dittner? Psychotic patients in hospitals mostly watch telly or sit around doing nothing much so any tired ness would be unlikely to be a result of exertion.

Chris cross-checked with the UK Biobank data and found no signal.

Being in hospital is exhausting for anyone in a reasonably normal frame of mind so 60% seems a remarkably low figure, but then by definition people with psychosis are not in a normal frame of mind and it is difficult to know how to interpret anything they say about themselves. So I think it...

I think we need to know that anti-CD38 is useful in a disease with known autoantibodies before playing with it in one that doesn't.

We did and Chris Ponting gave a useful commentary. The results were not replicated.

They quote a paper by Steiner, Scheibenbogen et al reporting an association between ME and PTPN22 alleles. Did we discuss that at the time, in 2020?

Well the parroting is there but not sure about the wooden leg

We get everything re-upholstered by Steve Marriage in Woodbridge who I imagine is a lot cheaper than anything in London - if the old chair is otherwise well suited. Transportation is an issue but men with vans seem easy enough to come by these days.

I thought we all knew the brain was connected to the body (it's called the neck). I thought the BPS mantra was about mind being connected to body. Four legs bad again?

Mmm... I think I prefer the dead parrot sketch.

Well there's always the dead parrot sketch.

But would a young lass fro' Yorkshire have owt to do wi' it? Maybe if she knew that where there's muck there's brass (to rhyme wi' the US pronunciation of ass).

I think the power imbalance in these situations may just be a function of how things have to be. It is the application that brings problems. What in my experience can transform a situation? One is a change of personnel. A different health care professional may handle a problem much more...

Which is the standard approach to PWME.