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  1. Sean

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    Yes, they just elide straight over that critical bit, making sure to never examine the possibility that patients' reluctance to push through PEM is completely justified. IOW, that patients are actually interpreting the somatic signals from their bodies correctly. As they have been doing for...
  2. Sean

    News from Scandinavia

    And as an excuse to not look for any.
  3. Sean

    #ThereForME campaign / Building an NHS that’s there for Long Covid and ME

    Yes, patients need to be a lot more careful about we wish for. Something is not always better than nothing.
  4. Sean

    Review Prevalence and Impact of [PEM] on Recovery in Adults with Post COVID-19 Condition. A Systematic Review with Meta-Analysis, 2025, Pouliopoulou et al

    And mine. Even if some form of carefully titrated exercise is safe and can help reduce long-term secondary consequences of ME/CFS (mainly cardiovascular deconditioning related, I presume), there is no good evidence that it actually reduces the primary symptoms and burdens of the disease and...
  5. Sean

    Achievements of Artificial Intelligence (AI)

    This demonstrates the one thing I think AI is good for, big improvements in efficiency at dealing with large datasets. But I seriously doubt that it is going to deliver amazing new conceptual insights, of itself. Seen no evidence for that thus far.
  6. Sean

    Stat News: NIH must address the twin crises of long Covid and ME/CFS — together

    Including ME/CFS within RECOVER’s scope is not just an opportunity — it’s an imperative. Hard agree. Even if ME/CFS & LC turn out not to be exactly the same, they clearly have a huge overlap, and resources will be much more effectively spent studying them together.
  7. Sean

    Retraction Watch: Editors resign from Springer immunology journal to launch nonprofit title

    Few things in this world need tearing down more than the parasitic and corrupting for-profit peer-review journals.
  8. Sean

    2025: The 2019/24 Cochrane Larun review Exercise Therapy for CFS - including IAG, campaign, petition, comments and articles

    Which, presumably, is why they pushed Peter Gøtzsche out, as his work on stuff like placebo effect sizes and problems with unblinded subjective outcomes was exposing them and their sub-standard methods and bogus claims.
  9. Sean

    Predictors of Cardiovascular Symptoms Among Long COVID Patients: Data from the Polish Long COVID Cardiovascular, 2025, Kapusta et al

    Results Of the 704 patients analyzed, 71.9% were female with a median age of 54 years (IQR: 45–64). Cardio-LC patients had statistically significant differences relative to the non-LC group in terms of blood pressure, elevated LDL cholesterol (p = 0.010), and non-HDL cholesterol (p = 0.013). In...
  10. Sean

    Maeve Boothby O'Neill - articles about her life, death and inquest

    Any time somebody in authority uses the word 'feel' they are avoiding responsibility.
  11. Sean

    2025: The 2019/24 Cochrane Larun review Exercise Therapy for CFS - including IAG, campaign, petition, comments and articles

    Yes, interesting double standard: Subjective self-report from patients is adequate to claim therapeutic benefit, including in the absence of support from objective measures, while also being insufficient to warn of harm, even though harms require a much lower threshold to trigger concern. Maybe...
  12. Sean

    Effectiveness of a personalised self-management intervention for people living with long covid (Listen trial), 2025, Jones et al

    The LISTEN trial illustrates the need and value of further research in to personalised treatments delivered by a multidisciplinary team in community settings and people's homes. It does no such thing, you liars. Just in case anybody doesn't know, in the south of the USA, at least, that is an...
  13. Sean

    Exertional Exhaustion [PEM] Evaluated by the Effects of Exercise on [CSF] Metabolomics–Lipidomics and Serine Pathway in [ME/CFS], 2025, Baraniuk

    Exercise led to consumption of lipids in ME/CFS and controls while metabolites were consumed in ME/CFS but generated in controls. Interesting, if it holds up.
  14. Sean

    NHS: GP surgeries; privatisation; physician associates

    One serious indicator of a failing state is their inability to train up, and retain, their own citizens for technical positions in particular. The same problem is happening here is Australia. The health system is being flooded by people from overseas. Not just the health system, all sorts of...
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