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I think what many ordinary people have in their minds, much the same as what medics have in their minds, is that if there isn't a clear biological explanation then it must be all in the mind. So ME/CFS is captured by the default assumption, not that people have a specific opinion on it. But if...

Hi Woolie, great to see you again - though I may have missed you previously. That's true - here's one at the top of the tree on Google https://www.nature.com/articles/s41562-024-02076-3 At the same time, research studies are always strongly skewed to higher SES, amongst many things. Yet for 15...

I don't know if the Webinar info on SequenceME and Long Covid has been discussed before. I found it pretty interesting transcript: CHRIS DecodeME is only finding some of the genetics. Sequence ME and Long Covid would find more of the genetics beyond what we've already found and that is...

If that's what they believe, it would help to spell it out in the context of why they think DecodeME supports their current work on drugs. Each specific signal is important, a finding point pointing to biology. And for each of these, compared with controls, there is no signal in controls. P<...

Re molecular biologist Marte Kathrine Viken at Oslo University Hospital (OUS), who has herself researched ME and genes. That sounds very sensible Re Prof Tronsdat I wasn’t aware that we were making any progress towards treatment. The immune system and the nervous system are very broad areas...

It's a wonderful opinion piece by a medic who has clearly retained his compassion throughout his career. Combination of better hours with your poetry is powerful, and suggest that the editorial board really understand understand your poem, and hopefully the biggest issues as well. Thank you...

This starts off brilliantly and cover the GWAS itself well, right up to the 8 genetic signals. At which point it veers off course. The blog ignores the analysis identifying the most likely ggene candidates and puts a lot of emphasis on associations between lother genetic findings the regions...

Most of this thread is way over my head, but I thought I'd comment on this approach (not necessarily this paper from the team), which was much discussed at the time. The study had been years in the making, and I found it a bit disappointing as a model. they used the shoulder fatigue scale to...

Thanks. There were no HLA/MHC gene flagged as likely candidates in DecodeME. Excluding HLA, do you have any feel for what percentage of human genes are immune ones?

Could you clarify that, please? The way it was explained to me, magma looks at the set of 13 genes only, and compares them with other genes. It doesn't look at any other ME/CFS genes. Are you saying that's not the case? I may have misunderstood you or what was explained to me originally.

It sounds like an interesting thing to do. But he thought anyone commits resources to do any experiment, it would be useful to have the planned analysis narrow down the like candidates. Which would also presume they have a big impact on the credible hypothesis. Maybe it's because I've been ill...

Maybe a better way is to estimate the number of immune genes. I found one at about 1600 genes . https://pubmed.ncbi.nlm.nih.gov/15789058/Let's say 2000 – or about 10% of all human genes. As far as I can see, quite a lot more than 10% of candidate genes linked to the DecodeME genetic signals...

On the face of it, the magma analysis is the stand out finding, and highlights stuff going on in the brain. However, my understanding is that magma is not as robust as the EQTL analysis, though I think that's probably debatable. I think that's the reason why the authors is placed less...

I'm not sure that is the case. The first thing they look for is the genetic signal, then they look to see what was captured by that genetic signal. I think that was mainly protein coding genes. I had a feeling there was at least one RNA species. I don't know if that showed up in the...

I remember talking to Chris Ponting this study years ago, and the possibility of a study focused on immune genes. These are much more affordable. His comment was that these kind of targeted genetic studies used to be very popular, but have a poor track record on replication. And that's when...

Possibly Veronica's finest so far. Yes, heartbreaking.

Good analogy I'm pretty sure genes identified by GWAS make identical proteins, and variants instead alter gene regulation, usually not by very much. That's one reason why effect sizes are small. So it may be that the dam is stronger because a bit more of this protein is produced. But the...

How sure of this can we be at this stage? The two specific bits of evidence I'm aware of, the most relevant CA 10 for pain, which is directly affects neuron. However, there's also a microglial gene. Microglial are glia not neurons. Then there are the 13 tissues where candidate ME/CFS genes are...

I would say the gold standard is diagnosis by expert clinicians. We know from a couple of studies that half of GP diagnoses are wrong – and almost all cases because that had been other, undiagnosed diseases (mostly biomedical, but also psychological) that explain the symptoms. I suspect the...

Thanks, both. That have been my understanding, but I wanted to check it. ADDED and I think this is an important message to convey to people who understandably wonder what the relevance of this big genetic study is to them when many won't have the relevant genetic differences, and heritability...