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See thread about an upcoming Canadian conference: Canadian Collaborative Conference on ME, November 4-6 2025

Thread for a Teclistimab study: BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease 2025 Bucci et al.

Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression Ying Jin, Genevieve H. L. Roberts, Tracey M. Ferrara, Songtao Ben, Nanja van Geel, Albert Wolkerstorfer, Khaled Ezzedine, Janet Siebert, Charles P. Neff, Brent E. Palmer...

I would think upregulating receptors related to learning would happen in specific locations in the brain relevant to learning, but figure 2B seems to show that AMPAR density was increased pretty much everywhere in this study. Would be good to know in what regions learning increases AMPAR...

Some posts about chronic traumatic encephalopathy have been moved to: Traumatic brain injury - similarities with and differences to ME/CFS, including PEM

I may be wrong about the motivation for IOM being specifically clinical use and CCC being research use, that's just what I recall people saying. But it does look like the IOM criteria is what the CDC in the US recommends for diagnosis. There's also the even newer NICE criteria, which as far as...

The newer IOM criteria, that I gather is supposed to be more appropriate for clinical diagnosis, and less related to ensuring homogenous research groups, doesn't say there are any excluding diagnoses, as far as I'm aware. Just a collection of symptoms - if you have them, you have ME/CFS.

What do you mean by "facilitation"? I was wondering about what prevents allowing unlimited viewers to watch (if the video streaming license allows) but not interact at all, and can't think of how that would make things harder. I suppose maybe they want to allow some questions from online...

I think it'd be helpful to the author and others to say why it's wrong, or at least to link to a correct definition.

Several posts about an upcoming MRC meeting have been moved to: MRC/NIHR DecodeME Showcase meeting online and in person Nov 6th

What is even the reason for limiting virtual attendees?

Autoantibodies against type I interferons are a prominent feature in SARS-CoV-2 fatal disease and hospitalization Rebeca Linhares Abreu Netto, Catherine Chen, Victor Irungu Mwangi, Carlos Eduardo Padron de Morais, Mariana Simão Xavier, Luiz Gustavo Gardinassi, Emily Marie Eriksson, Nicholas...

New preprint with further analysis of this data (link to thread): Analysis of Potential Subgroups in Vaes ME/CFS Patient Clusters, 2025, Squires

Refers to this study (link to thread): Symptom-based clusters in people with ME/CFS: an illustration of clinical variety in a cross-sectional cohort 2023,Vaes,Jason et al

Analysis of Potential Subgroups in Vaes ME/CFS Patient Clusters Erik Squires Background: Vaes et al. (2023)[@vaes2023] identified 13 symptom clusters in a large cohort of ME/CFS patients. Symptom intensity is broadly correlated with post-exertional malaise (PEM) severity, with variation across...

A post about the NICE Clinical Knowledge Summary was moved to: NICE Clinical Knowledge Summary (CKS) on ME/CFS, July 2025

Old papers, so maybe no PEM in some cases, but doesn't look like any striking differences: Dysregulated Expression of Soluble Immune Mediator Receptors in a Subset of Patients with Chronic Fatigue Syndrome: Cross-Sectional Categorization of Patients by Immune Status, 1995 Dysregulated...

No significant difference, but it looks like the measurement was between different ME/CFS subgroups (infectious onset or not, or having certain genetic alleles), and not compared to healthy controls.

Yeah I just think there may or may not be certain subjective and objective measures that can be influenced by expectations. I certainly think it's unlikely that all objective outcomes could be influenced by expectations. If a patient got a placebo and was told it was a drug designed to...

Maybe we're working with different ideas of what placebo means. I would consider if someone swore that they felt feverish after taking no medication, even if a thermometer does not indicate any higher temperature, would be a placebo effect. The effect would just be on the subjective feeling of...