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Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide Lael M. Yonker, Abigail S. Kane, Zoe Swank, Lena Papadakis, Victoria Kenyon, Samuel Han, Rosiane Lima, Lauren B. Guthrie, Bryan Alvarez-Carcamo, Manuella...

Really beautiful poem by James Strazza from the video above, transcribed for those that can't watch: "Everything will be okay" Rammed down my throat like Soviet propaganda. "Everything will be okay" As if life were a film and I were the lead. Privilege preached as prophecy. Luxury assumed...

Email Newsletter (sign up to get the newsletter here): Filming the extremes From a dark room to busy streets Trent has been traveling. Camera on. He spent a couple days in South Carolina with James Strazza and Galen Warden filming their heartbreaking story. We released their teaser just...

Africa Foot: 'Health Concern Forces ex-Bafana Bafana Star to Step Away from Game' 'Former Bafana Bafana goalkeeper Jethren Barr is stepping away from his football career as he’s taking a break due to illness. After a two-season spell with Irish club Drogheda United FC, Jethren Barr became a...

Derbyshire Times: 'Celebrating Kara Jane’s legacy with posthumous album launch & fundraising event' 'A second album is due to be released on August 8, on ‘Severe ME Day’, to remember and celebrate the legacy of Shirebrook singer-songwriter Kara Jane Spencer, who passed away of ME/CFS aged 32 in...

Another good starting point is the ME/CFS paper you get a gene from in the first place. The authors are likely to have done at least a scan of the literature to see how the significant genes might fit into the explanation for ME/CFS. So they did a bit of the work for you, and you can check if...

I'm learning just like you. But I think just read about it and then read about it and then read about it some more and then read about things related to it and hope a connection comes to you that might just possibly make sense in the context of ME/CFS. I don't know how useful GTEx is. I just...

Just finished reading this, and wanted to express that it's clear from this text that we're very lucky to have Chris Ponting at the helm of DecodeME. (Not that it wasn't clear for a variety of other reasons.) Thanks to all the authors here for doing the work to make sure the statistics get done...

DCC was significant in a recent ME/CFS genetic study: https://www.s4me.info/threads/neurodevelopment-genes-encoding-olduvai-domains-link-myalgic-encephalomyelitis-to-neuropsychiatric-disorders-2025-lidbury-et-al.44671/post-619252

Large-scale genome-wide analyses of stuttering Hannah G. Polikowsky, Alyssa C. Scartozzi, Douglas M. Shaw, Dillon G. Pruett, Hung-Hsin Chen, Lauren E. Petty, Alexander S. Petty, Emily J. Lowther, Shu-Hsien Cho, Yao Yu, 23andMe Research Team, Sahar Mozaffari, Christy L. Avery, Kathleen Mullan...

Now published: The Psychological Benefits of Forest Bathing in Individuals with Fibromyalgia and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Pilot Study Mayte Serrat, Estíbaliz Royuela-Colomer, Sandra Alonso-Marsol, Sònia Ferrés, Ruben Nieto, Albert Feliu-Soler, Anna Muro...

Ok, I wasn't positive if the OR is always based on the minor allele frequency, but that's probably right. I got the same. Edit: So I think that means the gene expression database is saying that if ME/CFS has the T allele less often, expression of CCK would be higher in cultured fibroblasts and...

Good thought, I'll send a quick email to him.

So the only significant finding in terms of genetic mutations was a SNP which affects the expression of CCK (aka cholecystokinin). The database they used seems to say that this SNP decreases expression of CCK in cultured fibroblasts but increases expression in colon cells. I couldn't figure out...

Functional Connectivity Changes in Long-Covid Patients with and without Cognitive Impairment Manuel Leitner, Daniela Pinter, Stefan Ropele, Marisa Koini [Line breaks added] Abstract Long-Covid is associated with cognitive deficits in memory, attention, or executive function. However, the...

Beyond fatigue: an intersectional analysis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and social identities Zoe Sirotiak, Emily B. K. Thomas [Line breaks added] Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, chronic condition...

I'm not sure that it's been studied much. I was mostly just extrapolating based the potential link in long COVID. Though even if severity isn't associated with ME/CFS, it seems likely that frequency of getting infections would be associated. If someone never gets infections, they can't get a...

Epigenetics/DNA methylation They continued by testing methylation differences between ME/CFS and controls. DNA methylation is the biological process where methyl group molecules are attached to the DNA at specific locations, which affects the expression of genes, but the DNA itself doesn't...

I'm interested in this study because the following review found that, out of the six GWAS/TGAS that had been performed prior to 2020, only this one performed all the recommended quality control checks for a GWAS: Review of the Quality Control Checks Performed by Current Genome-Wide and...

Final paper published December 2018: Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Santiago Herrera, Wilfred C. de Vega, David Ashbrook, Suzanne D. Vernon, Patrick O. McGowan [Line breaks added] Abstract Myalgic Encephalomyelitis/Chronic...