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  1. hotblack

    UK Action for ME Big Survey 2025 - closes 27/1/26 (UK residents only)

    I’m not sure they do. I’m also not sure if it matters for the goals? This is in their FAQ
  2. hotblack

    UK Action for ME Big Survey 2025 - closes 27/1/26 (UK residents only)

    It is indeed a big survey. But we have plenty of time to complete it and can save our progress. There’s also a version to print and they seem to be offeribg some phone support for people who need it. They were also great at engaging earlier on in the design process. Lots of positives here, well...
  3. hotblack

    Norwegian Fluge & Mella daratumumab Haukeland trial 'ResetME' now accepting international donations

    And already a third of the way to the new target! Nice work :)
  4. hotblack

    Open DSQ PEM survey - DePaul University, open October 2025

    It’s a shame the factsheet hasn’t been read and there’s some misunderstandings here. I completely get what you feel and felt a bit the same at first tbh. I wonder if there’s perhaps a difference or clash in style adding to things here? The length of the response and the point by point detail...
  5. hotblack

    Open DSQ PEM survey - DePaul University, open October 2025

    Some great comments by others which I support and @Nightsong highlights how important it is to get this right. And thanks to @TheDePaulGroup for the involvement and comprehensive responses so far. While we’re discussing differences there is a lot of shared understanding in here too I think...
  6. hotblack

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    I don’t think so and this was the question I had in the other thread about mechanisms of resistance to daratumumab in multiple myeloma There seems to be a lot of focus on NK cell quantity but less on other details which could be important here. I’d like to understand more or find out if studies...
  7. hotblack

    Microsoft releases quantum chemistry tool Skala

    I found this interesting in general and thought others would. A scientific development with potentially relevant applications and also ties in with recent discussion of usefulness of AI/ML. I also think it’s an area @Jonathan Edwards is very familiar with!
  8. hotblack

    Microsoft releases quantum chemistry tool Skala

    Microsoft AI Research has made a tool called Skala available for everyone to use. It was previously an internal research project. Here’s the new Azure Skala page. What is this all about? There’s some info this webpage about the DFT research project Most accessible is probably this blogpost...
  9. hotblack

    Norwegian Fluge & Mella daratumumab Haukeland trial 'ResetME' now accepting international donations

    Great work @Joan Crawford and thank you, am sharing where I can to try and get some eyes and donations to help your efforts
  10. hotblack

    Open DSQ PEM survey - DePaul University, open October 2025

    Agree that focussing on predefined activities is the wrong path. Different people of different severities with different levels of support prioritise different things. This just isn’t an accessible questionnaire, in size or structure. I gave up on it. I believe there will be self selection in...
  11. hotblack

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Oh yeah… I’d missed that! Thanks both for the explanation. Thanks for the insight. Useful to know.
  12. hotblack

    Trial Report Relationships Between Fatigue, Cognitive Function, and Upright Activity in a Randomized Trial of Oxaloacetate for [ME/CFS], 2025, Vernon et al

    If you did want to Khan Academy has a couple of good modules This AP Biology one And this MCAT module
  13. hotblack

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Or they’ve got a good PR team? I was surprised to hear about it first from the media rather than here tbh.
  14. hotblack

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Yeah, I think some of as are roughly saying the same thing. Maybe with some differences in how we dress it up. Others seem to think it’s not worth pursuing at all. It seems clear from the factors raised by Chris Ponting and Kevin McConway that this shouldn’t be being reported as a test with the...
  15. hotblack

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    The section on diagnostic value has some interesting bits too. I don’t think they’re completely ignoring the limitations here and they do call this a proof-of-concept study And on use of their technology Here are links to the papers referenced in this section for people who want to read...
  16. hotblack

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    This on CD4 from the pathway analysis HLA-DRA also popped up in Fig 4 although I’m not sure of the significance. Some quotes on the potential for specific subgroups And
  17. hotblack

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Why? In my mind seeing if they can reproduce the results, albeit while resolving the concerns raised, is exactly what we need.
  18. hotblack

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    There’s definitely lots of the usual narrative of inflammation, neuro-inflammation, dysregulated immune states, etc. It has the feel of one of those papers which is trying too hard in parts and perhaps doesn’t try hard enough in others leaving me questioning the findings the more I read...
  19. hotblack

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Thanks. Really useful to have your thoughts and look forward to others too. There seems to be a lot of the usual framing throughout but wondered if there may be something there nevertheless. But am having difficulty getting my head around it all and am not sure if that is the paper, the...
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