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Counterpoint is this recent paper in Nature, which suggests that we simply need bigger sample sizes and more detailed measurements of all SNPs, including rare ones. Estimation and mapping of the missing heritability of human phenotypes | Nature

I thought they compared identical with non-identical twins, so that environmental confounders are substracted (as they are present in both pairs of twins).

Some weird sentences:

Another increasing issue is AI-created summaries on social media. Researchers often oversell their findings in the paper, and it seems that AI then inflates this even further. Don't have an issue with using AI per se (it can be useful in many situations), but the LLMs people use don't think...

Researchers from the University of Vienna are developing a new PEM questionnaire. https://www.soscisurvey.de/V-PEM-AQ_english/ Shared by Rob Wust on Twitter:

Probably not much to see here. The study has a small sample size (27 LC patients) and the authors measured mitochondrial mass and membrane potential in 9 different immune cell types. That's 18 different comparisons, and it looks as if no correction was done for multiple testing. So it should...

Some questions were raised about the NHIS survey data in this thread: https://www.s4me.info/threads/cdc-data-brief-myalgic-encephalomyelitis-chronic-fatigue-syndrome-in-adults-united-states-2021%E2%80%932022-2023-vahratian-unger-et-al.36480/post-566066 In the 2023 NHIS survey, the prevalence of...

"The authors declare no competing interests." Jeff Wood's website: "I now work as a consultant to chronically ill patients, as well as to researchers and MDs who serve the chronically ill community." https://www.explorewithjeff.com/

See what you mean. They show that lupus patients have an increased number of these EBV-infected B cells, that these are reprogrammed, for example, to remain active, and present antigens, that they respond to antinuclear antigens, and that they can activate T-cells. But the smoking seems to be...

Sounds interesting, anyone able to share a copy?

Great news! I wonder what they mean with post-infectious disease: is it ME/CFS and Long Covid, or other diseases as well?

Looks like this is just based on self-reported questionnaires. Don't think one can study MCAS by just asking patients if they report certain symptoms or responses to treatment.

Here's the link to that previous study: Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients - ScienceDirect Looks like in other disorders such as schizophrenia, reeling has mostly been found to be...

Should we have a closer look at reelin? Both the blood marker and gene expression were increased in patients. This team has reported this before in LC. Here's the wikipedia description:

Do less viruses in the blood of ME/CFS patients mean something about their immune system or is the most likely explanation less contact with other people and therefore less exposure to viruses?

Think it might help if people are outspoken about this on social media. For example, regarding the 'ME is not CFS' debate, there is this sense that patient organisations and researchers conflate the two out of opportunism. And that the non-severe patients don't get the difference and are happy...

Hermisson et al. Pflegeanleitung für schwer- und schwerstkranke ME/CFS-Patient:innen Resource for severe ME/CFS in German (including automatic translation in English) Document | Thread

Suspect it was normalized. Either way, they report the minimal clinically significant improvement to be 10 points. So the mean improvement was lower than this, despite having no control group.

Made a brief summary of David Tuller's interview with Prof. Hughes: 1) Interesting interview of Prof. Brian Hughes by David Tuller. In his new book Hughes argues that psychology is not woke but that its methods are essentially conservative because it focuses on an individualistic view and...

Perhaps a bit off-topic, but was wondering if ME/CFS is like sickness behavior, why we don't see more loss of appetite.