Search results

Posts on the topic of access to PACE trial data have been moved to https://www.s4me.info/threads/pace-trial-data.2337/

The starting point and the wrapping of this study is that fibromyalgia is the result of stress. The arguments for that are weak, with the issues including the validity of the assessment of depression in people with a debilitating chronic illness and with pain. And this study did not find a...

But that's not good enough. I'm sure the BPS crowd think that they are giving patients some control and a chance of symptom relief and hope. But their ideas don't work. Hope based on poor advice can harm. We can't fairly criticise the BPS proponents for pushing unevidenced treatments and...

A number of posts about whether, and how, people diagnosed with ME/CFS should be told about their prognosis have been moved to https://www.s4me.info/threads/me-cfs-and-permanency.8424/

We have a thread on vagus nerve stimulation.

A number of posts discussing psychosomaticism and magical medical thinking have been moved to Psychosomatic medicine and the psychologising of physical diseases

:) This has made my day. Congratulations to Daniel.

There are some interesting paragraphs about autoimmune disease and NETs in the 2020 paper. There have been studies finding neutrophils from people with lupus or rheumatoid arthritis are more likely to produce NETs when stimulated than neutrophils from healthy people. It would be good to see...

NETs are thought to be formed in three ways: Vesicle-mediated release - vesicles wrapped with DNA come out of the cell nucleus and travel to the cell membrane where they fuse with the membrane, to release the DNA. Cell lytic - the cell and the nuclear membrane breaks up, releasing the DNA...

Neutrophil Extracellular Traps (NETs) are potentially of interest to us. This image from a 2020 paper by a Chinese team (Neutrophil Extracellular Traps: Signaling Properties and Disease Relevance Tiewei Li, Zhengyan Zhang, Xiaojuan Li, Geng Dong, Min Zhang, Zhe Xu, and Junmei Yang) gives a feel...

:laugh: Thanks for digging out those articles dreampop. Very illuminating.

This paragraph seems worthy of looking into more. So, they are suggesting that males have higher inflammatory responses than females. And that, when mice are subject to traumatic brain injury, the male mice are more likely to exhibit neuroinflammation than female mice. So, this suggests it is...

Last day - if you haven't voted yet, today is your last chance. Scroll down to Daniel's picture, click on it to select it, and scroll down to click send. (The cutoff is probably relative to Australian Eastern time)

A study by Leonard Jason's team compares Japanese and US patients: Journal of Preventive Medicine & Healthcare: A Comparison of Patients with CFS and ME from USA and Japan - 2021 - Jason et al Disappointing to not see a Japanese author on the team; it would be interesting to get feedback on the...

Checking the authors, none are Japanese. It seems a bit odd in 2021 for researchers to be drawing conclusions about the impact of cultural and socioeconomic factors such as disability benefit access without the benefit of a person from that culture on the team. The acknowledgements section...

Wonderful

I thought the same Andy, but then I watched it. Actually I think their insight is quite profound. :) I recommend watching it. I'll put a spoiler here for those who can't watch it.

If I have anything wrong (and I'm sure I do), please let me know and I'll correct things - or post below. The meeting was a bit like drinking from a fire hose, with a lot of information and a lot of people coming from a lot of different backgrounds with different levels of knowledge about Long...

I attended the Long Covid Alliance meeting earlier today, representing S4ME. There was quite a big group attending, maybe 45? at a very rough guess. Like David, I was struck by the range of organisations and outlooks represented in the alliance. That can be a strength, but it is also going to...

Thank you Matt. I found your essay very powerful, and sad, and the Angel from Montgomery song was both of those things too. I'd quote the last bit of the essay, as I think there's a lot of wisdom in it, but I'll leave others to get to it themselves.