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Blood volume studies So, this comparison only involved the participants from the MAIEPO study (56 CFS and 21 controls), using data from that study. Note the 21 controls versus the 24 that started - the data for three was excluded for 'technical reasons'. The total blood volume and plasma...

I would have thought the relatively low effort involved in spitting in a tube and sending it off would go a long way to work against participation bias. It's interesting to see the problem being identified with the UK biobank, which presumably also has a low effort requirement. It's interesting...

A post on participation bias has been split to create a new thread: Participation bias

Participants The CFS participants (56 of them) came from a prior study (MIAEPO). CFS diagnosis was based on the participant providing evidence of a diagnosis by a physician, later confirmed by an interview and questionnaires. 24 of the control participants came from this study - low blood...

https://portlandpress.com/clinsci/article-abstract/118/2/125/68670 Scihub 2010 paper Barry Hurwitz; Virginia Coryell; Meela Parker; Pedro Martin; Arthur LaPerriere; Nancy Klimas; George Sfakianakis; Martin Bilsker Abstract The study examined whether deficits in cardiac output and blood volume...

Yes, I've wondered if reaching out to him might be good. But, at the same time, I feel as @Ravn said, it's his truth. It feels maybe unreasonable for someone to bear the weight of expectation of a whole illness community when they write about their own experience...

I feel a bit, ambivalent?, about this interview. It was mostly about his two books, although David gave a very good description of the cognitive challenges of ME/CFS. I think the casual listener would have understood that ME/CFS is very debilitating, and the interviewer was, as she has been...

This item will be on Radio NZ in an hour or so - was promoted as the person having 'ME', although I see the schedule refers to 'chronic fatigue'. edit - here's some more:

No indication of how many people received the survey in the abstract. So, there's no way to put the number of people affected by Long Covid, or burnout, into context. Even in the paper itself, we are left with very little idea of what proportion of senior doctors were affected by anything...

It's not just for screening? You'd hope a GP could ask the questions needed to rule out a psychological cause for symptoms, but I guess seeing a psychologist as part of a screening process could be defended. Especially for a child, who might not be able to articulate their concerns well, or...

Oh, that is a shame. Yes, his response to the 'are you depressed' question in that first interview indicated very clearly, I thought, that mental health issues weren't the problem. I guess it highlights yet again the danger of having any well known person becoming the poster child for the...

Yes, it's a problem. The suggested comparison might allow for some analysis of the issue around time to diagnosis. The DecodeME study is an exciting opportunity to answer some of the epidemiological questions.

I think rather than trying to do analyses on this patient survey 'year of onset' data, which will have all sorts of biases, it would be much better to use the Norwegian Patient Register data. That register data does have a few problems, but far fewer than the patient survey. It would be a...

(crosspost with Art V.) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189623/ This is the famous twin peaks study. Presumably that Patient Register could be examined to get quite comprehensive incidence data since 2012. (I do question the faith some people put in the idea of the twin peaks...

Lots of people have been very critical of this woman and have suggested that she doesn't have ME. It's hard to know what we all have of course. But I am not so sure that it's a misdiagnosis. My daughter dragged herself through national level karate competitions, captained her school rowing...

While we wait to see the published article, here's my understanding of Paraphrasing stuff on the Wikipedia entry for ADE: An example where this occurs is dengue fever infection. There are four different serotypes of dengue virus. Typically the first time someone is infected with, for...

Links: UK CFS/M.E. Research Collaborative [CMRC] conference, 10th and 11th March 2020

https://www.frontiersin.org/articles/10.3389/fmed.2021.662513/abstract (provisionally accepted - article will be published soon) Brett A. Lidbury Research School of Population Health, Australian National University, Australia In Frontiers of Medicine - Infectious Diseases - Surveillance...

That seems to be quite a structural problem. I think we've talked before about the idea of governments giving selected universities funds to replicate studies. That way, everyone has better information, universities have money and students learn to do really good research (as opposed to...

If making it cheaper opens up a vast weight loss market, then it might make sense to do so. Yeah, that was my vague thought, if the drug is based on a naturally occurring hormone, then maybe all relevant options can't all be tied up with patents. And maybe it's possible for modified bacteria to...