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They screened, 464 SNP’s, and the study make no mention of correcting for the many comparisons (they said they set the value at p less than 0.05: they would be talking about q values if they had corrected for multiple comparisons). This looks like a study of false positives (this team has made...

Thanks. Unfortunately, I don't have the energy to tackle another thread. Do you know if it covers research that addresses the issue of PEM after mental triggers vs PEM after physical ones?

Very true, but I wouldn't expect the same person to experience PEM differently post phy or mental triggers. Especially as PEM is usually seen a (body) global issue, not something localised such as muscle pain This is why I think we new evidence: we know so little about PEM, not least the...

I broadly agree with your very broad and important point, and Occam's Razor is with you. Though I wouldn't completely rule out there being independent types of mental and physical PEM (because a small but significant proportion of pwme have no mental-triggered PEM and some here report mental...

Are these Newton papers relevant? I haven't looked at them for years and you might well be aware of them in any case. I'm not sure this work was ever followed up properly. https://scholar.google.co.uk/scholar?q=newton+cfs+31-p&hl=en&as_sdt=0&as_vis=1&oi=scholart

Maybe I missed you doing so earlier, but could you say more about this expert interpretation?

Published here. No prizes for guessing who the S.M. of the poem is, and I was deeply touched to have such a wonderful poem written for my birthday. Thank you, Veronica.

I'm very interested in the similarities or not between brain and body PEM triggers. But I'm not sure your point necessarily follows given that ME is such a heterogenous illness and many researchers it's more than one illness. Neurocognitive issues are incredibly common, typically over 90%...

But does that study have an opportunity for feedback (I bailed out because the questions didn't fit my experience)? Otherwise, I think it's pointless; the questionnaire needs fixing before this becomes a 'validated' instrument that has been developed without proper patient input.

I gave up on the questionnaire because 1. triggering options included toxic mould but not viral/other infection (only specific ones that most will not be familiar with) 2. none of the "what's most important to you" questions really fitted what I would have put, and the questions/answers about it...

I'm still hoping that GWAS will provide powerful clues about what is causing ME/CFS (because genetics is ideally suited to identifying causation). That said, I think this study is very interesting: Ihad the impression that Wust and colleagues know what they are doing in this field (though I...

Great result - don't know if you need a reminder still? I think RW would find the discussion interesting, particularly about creatine kinase and the recent post by @SNT Gatchaman That's a good point about the modest impact of thinking on overall brain energy consumption. But maybe that's not...

Interesting comment from Alan Carson, President of the FND Society, asking for a bedrest comparison. He should read the analysis here. someone here (@ME/CFS Skeptic ?) has already pointed out the long Covid patients averaged 4000 steps a day: bedrest is not a relevant comparison. Plus, as Rob...

I hope others can help me understand this paper as it would take me a long, long time to the full thing. It appears to be very thorough. The findings are eye-catching but also report numerous negative findings, including the absence of microclots in capillaries (I'm concerned when everything...

As you can see below, these results from stimulated frozen CD8+ cells (vs fresh in this study) show no difference : Yes, that makes sense figure 8 Figure 8. Production of cytokines by T cells in response to stimulation in vitro. PBMC from mild/moderately affected ME/CFS (ME-M: n = 76)...

Sorry, I had completely misunderstood things, but it’s still very good news!

It seems a long shot, but it's good that they are not just looking at antibody binding but also at whether or not the binding affects the activity of the receptors they bind. Via @Sid They don't lack ambition.

these are amazing results, and show the value of all the effort to compile the news and brief. out of interest, are they based on links back to the news in brief page?

I was thinking n = 30 to 40 per disease group, not hundreds. Presumably processing, fresh blood isn’t so difficult for an immunology lab? And they were providing the assay as suitable for adapting for clinical use, which would be at scale. I can’t think of this research can advance without...