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  1. Sid

    Special Report - Online activists are silencing us, scientists say Reuters March 2019

    Very weak article. First of all, none of those tweets are 'abusive' or threatening. Being rude is not a criminal offence (yet). These 'professors' just want to go back to a time when they could issue their ex cathedra pronouncements with no pushback whatsoever from the masses and no...
  2. Sid

    MitoQ spam email warning

    Pretty much.
  3. Sid

    MitoQ spam email warning

    I know this is an old thread but I just wanted to say I also received this phishing email and although I did not click on the link or give the scammers any information, my contact details were clearly leaked from that website hack and I had to change my phone number (as I started receiving weird...
  4. Sid

    Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients (2019) Tomas, Brown, Newton, Elson

    Good news IMO. Implies that nothing is structurally wrong with the mitochondria per se. Likely to be a signalling problem telling them to slow down energy production.
  5. Sid

    Cognitive-behavioural therapy v. mirtazapine for chronic fatigue and neurasthenia: randomised placebo-controlled trial (2008) Stubhaug

    Mirtazapine is one of the most fatiguing antidepressants. Possibly the most fatiguing there is. It's a great drug to use if you're trying to make CBT look good.
  6. Sid

    Trial By Error: The Cost of MUS

    Medically unexplained doesn't mean medically unexplainable. Just because medical science doesn't yet understand something, it doesn't mean it's imaginary. There is a certain arrogance amongst these "professors" of medicine (many of whom are clinicians with a few crappy published papers and only...
  7. Sid

    Daily Telegraph: Living hell or yuppie flu? The confusing fog of chronic fatigue syndrome

    These sorts of "yuppie flu" headlines will continue forever unless patient organisations start pushing back with complaints to authorities or even lawsuits.
  8. Sid

    Is PEM cumulative? - public thread

    Me too. Cortisol and adrenaline probably.
  9. Sid

    Effects of a health education program on cytokines and cortisol levels in fibromyalgia patients: a randomized controlled trial, 2018, Pernambuco et al

    Lots of psychotherapy trials use this design because it makes it exceedingly easy to show a statistically significant result in favour of 'therapy'.
  10. Sid

    Effects of a health education program on cytokines and cortisol levels in fibromyalgia patients: a randomized controlled trial, 2018, Pernambuco et al

    That's not a control group. This is a waiting list comparator arm, a useless trial design. A true control group would force these patients to get out of bed/house, show up to the hospital on the same schedule as the intervention group but have them play solitaire or read a newspaper instead...
  11. Sid

    Pseudobulbar affect anyone?

    Sorry to hear that. I didn't realise an old thread had been resurrected, just saw the dates now.
  12. Sid

    Pseudobulbar affect anyone?

    Hi @Justy, I too have experienced pseudobulbar affect, though not quite to the same degree of severity as what you've described. One of the old school books or articles I read on ME described it as being part of the clinical picture during the initial stages of the illness. I forget who said it...
  13. Sid

    Chronic fatigue syndrome in the emergency department (2019) Timbol and Baraniuk

    I seem to recall filling out their questionnaire. Useful study. My ED encounters (for what were OI flares in hindsight) have been uniformly negative, encountering people who ranged from criminally stupid or lazy to smart and compassionate but having no knowledge whatsoever of dysautonomia. It's...
  14. Sid

    Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

    I've had concerns about this line of research (on the other forum) since the MRC funding was announced for this project. Academic psychiatrists have been asserting for 20+ years that interferon-alpha treatment for hep C is a biological model of depression. There are 1000s of publications on this...
  15. Sid

    Ketogenic diet

    A recent low carb study engaged in outcome switching to obtain the desired result. https://www.biorxiv.org/content/early/2018/11/28/476655
  16. Sid

    Dr Alan Moreau's new, low-stress protocol for provoking PEM.[Thoughts?]

    I knew those endless hours of studying Latin declensions in junior high would finally pay off in a big way one day.
  17. Sid

    Protocol Faecal microbiota transplantation (FMT) in Norwegian outpatients with mild to severe ME/CFS: protocol (...), 2024, Skjevling et al. Comeback Study

    My onset was similar. From what I can tell, the current position of the medical industry is one of aggressive denial about the sometimes devastating and permanent alterations of the microbiome caused by (often needlessly) prescribed antibiotics, especially when given in infancy before a robust...
  18. Sid

    Dr Alan Moreau's new, low-stress protocol for provoking PEM.[Thoughts?]

    This would be in line with anecdotal observations discussed on other fora that massage makes many patients worse. I don't know that it's actual PEM he's measuring but it's interesting nonetheless that something this innocuous elicits symptoms and biological alterations.
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