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This is wonderful work. I haven’t seen some of these poems for a while, and some of the lines are startling: thank you, Veronica

Thanks. Could you explain a bit more about autonomic discharge, and also if that ties into the point you made earlier about a key role for the hypothalamus?

Me: how does the inhibitory signal model explains the consequences of overriding that signal? I was hoping that, at least in the case of illness, we would know what causes the reaction to overexertion – because that would good be a clue to what is going wrong in ME. Do you see a way to...

@Jonathan Edwards, how does the inhibitory signal model explains the consequences of overriding that signal? When we have flu or are ill and press on, we usually feel terrible soon afterwards. Is that an extra level of inhibitory signal trying to reinforce the message, or is the ill feeling...

That’s an interesting explanation for the lack of lactate production (I didn’t know about the lactase dehydrogenase issue)). But I don’t think it can explain the single maximal exercise test. One of the slightly surprising, but consistent findings is that the maximal exercise results for people...

Comment — does endothelial dysfunction play an important role in the illness? If replication shows that endothelial dysfunction is the norm in ME/CFS, that will be quite something. I'm not aware of any other objective markers linked to the illness. The bigger question, though, is whether or...

Comments The two striking things about the study are that: 1. This is the strongest evidence yet for endothelial dysfunction in patients, and is an important finding. 2. Potentially, dysfunction plays an important role in the illness, but the evidence for this is much weaker. 1. Important...

Just adding my thanks to @Dx Revision Watch for the detailed and relentless pursuit of this. I know that no other approach would work, even if I can’t follow all the details myself. I think you are doing a huge service to the whole patient community.

Striking results I don't think I've ever seen a set of results as striking as those in figure 2, so I am interested in the study. Here are some comments on it: Pros Prespecified miRNAs: they didn't just hook out a select set of nice 11 micro-RNA results from a much larger dataset, instead...

. I think phase 2 is the earliest stage of trial. It’s another drug targeting CGRP, but what makes it interesting is that it directly targets the brain. All the monoclonal antibodies target CGRP in the rest of the body because they cannot cross the blood brain barrier ( but they can bind to the...

Crossed with Chris P I don't claim expertise, but do know that the SNP identified is rarely the active, relevant DNA difference. Usually, it is simply a tag near the actual site of action (and sometimes even thousands of kb away). IT is not always easy linking SNP to critical genetic change...

In his large study of glandular fever, Peter White found that days of bedrest was a predictor of developing CFS. Bedrest is most obviously a marker of severity of illness, though Peter, White. chose to interpret it as a sign that excessive resting was a risk factor.

From a recent review on LC: The impact of vaccination on long COVID symptoms in people who had already developed long COVID differs among patients, with 16.7% of patients experiencing a relief of symptoms, 21.4% experiencing a worsening of symptoms and the remainder experiencing unchanged...

Joshua was working in Chris Ponting’s group, and his PhD was jointly funded by Action for. ME and the office of the Scottish chief medical officer. Kudos to Joshua and all involved. (With a nod to the company that did a lot of sequencing of Tcell receptors genes, Systems Biology Laboratory,).

If I’ve understood right, using best practice mathematical and immunological methods, Joshua did find a single genetic difference that was significant in Uk Biobank: for males with ME/CFS within the gene PDE10A. He also helpfully ruled out a number of other findings. This is what our field...

Thank you, I’m glad the issue will be clearly raised. Like many others, I’ve achieved that short term gain under the encouragement of a therapist, which ended in long term loss.

I know you and Adrian do, but unless the research group absolutely locks in subjective outcome measures to use only in blinded trials, I think the sf-36 is not a suitable measure. We'll just end up down the same rabbit hole as before.

Thanks. I would much prefer objective measures. but does the research group understand the prolem of using subjective outcomes in non-blinded trials?

It would be helpful to know the purpose of using the sf-36 scale. and apologies if this is posted earlier, I haven't been able to read the whole thread.

SF-36 Physical Function subscale I actually think the SF 36 scale provides the best available self-report measure of physical function (I'm not keen on the rest of it). It is quick to complete and can be done online and by thousands of people without access to special kit. Plus, it's widely...