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  1. V.R.T.

    Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment, 2016, Blank +

    Totally understandable! I remember trying to do academia with ME, it was hard going. Hope the collaboration requests are fruitful!
  2. V.R.T.

    Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment, 2016, Blank +

    How goes your quest for muscle samples? Appreciate you may not be able to divulge everything but curious to know how your work is progressing.
  3. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    So having reread this I think JE is talking about the inital Decode HLA analysis. And that it could well have picked out those connections but whatever it did pick up was discovered to be a computational hallucination so we were left with the DQ link. And I checked and DR is the HLA protein...
  4. V.R.T.

    Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment, 2016, Blank +

    The lupus connection again...
  5. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    Could you possibly clarify what you mean by this for laypeople like myself? Is DR the HLA that DQ is usually linked to but wasnt in DecodeME?
  6. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    Don't we have to wait for the HLA analysis before we can conclude that they didn't show up? I thought the whole point of that is that the normal GWAS method can miss a lot about HLA.
  7. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    This is what i was trying to get at earlier
  8. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    Yes, I misread the abstract somewhat!
  9. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    My brain fog is bad right now but couldn't these results suggest weak binding with all antigens rather than pathogen specific ones? As in immune dysfunction not viral persistance as the driver.
  10. V.R.T.

    Air Purifier for COVID

    I have the bigger one of that and I'm quite happy with it!
  11. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    HLA-C and DQB1! Does the conclusion they come to about persistent herpesvirus line up with the data? It doesn't look like they determined the binding affinity to other types of antigen. Edit: my mistake, missed the first part of that last paragraph.
  12. V.R.T.

    Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID, 2025, Liu et al.

    Eight individuals? Is that normal for this type of study? Sounds like they only studied eight acute covid patients and extrapolated about long covid from there? Is this a valid approach? This sounds like the sort of vicious cycle and the sort of treatment we have been speculating about on...
  13. V.R.T.

    Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID, 2025, Liu et al.

    What does this mean? Have we seen any of these genes before?
  14. V.R.T.

    Clare Gerada: influence on UK medical practice and ME/CFS management

    Its absolutely insane how many NHS staff still believe covid isnt airborne. This was Feb 2020 but could easily be Feb 2025.
  15. V.R.T.

    Clare Gerada: influence on UK medical practice and ME/CFS management

    That is very true, I did them a disservice!
  16. V.R.T.

    Clare Gerada: influence on UK medical practice and ME/CFS management

    This really shows how deep the 'blame and stigmatise the patient' rot goes. And that it was reinforced in training to treat the patient with suspicion. It must be your fault you feel ill. You must be an alcoholic (which is still a very stigmatised condition) or have AIDS (still an extremely...
  17. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    What are the possible culprits? Or would the list stretch from here to Jupiter...
  18. V.R.T.

    Clare Gerada: influence on UK medical practice and ME/CFS management

    Should this say 'doesn't '? It is absolutely galling that she and Wessely are allowed to pretend that they cared about people with ME/CFS whilst having devoted their careers to maligning us and doing away with ME/CFS as a diagnosis.
  19. V.R.T.

    Book - Psychology's Quiet Conservatism, 2025, Brian Hughes

    This is something I was getting at in another thread yesterday. This idea that you are responsible if you don't get better is so toxic. You see it so often now in discussions of mental health. X person doesn't deserve sympathy for their struggles because they are not being a good little patient...
  20. V.R.T.

    Ron Davis’s big immune study is looking at HLA genes (HLA, WTF?) Here’s the story. [Simon M blog]

    Well, it seems like the results of this never appeared. Does anyone know if it was abandoned or if its been postponed for some reason?
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