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Were the adjusted p-values used in the paper? I see that there are FDR values in table S2 for the pathways, in which only vitamin B6 metabolism is below .05. But the text and figure 1A seem to be based on the raw p-values.

Oh okay, I thought you were mainly aiming for the binning aspect, not necessarily keeping it asymmetrical like a standard histogram.

Oh I understand. Basically bin them to the width of one of the circles. Yeah, I mean like here's a paper where after they corrected an error in their plot, they switched to the binned dot plot/histogram type visualization. I like the exact values on the left better. Edit: But I can see an...

I'm not sure what you mean by round to the nearest point. Is it difficult to compare groups in the plot I shared? Along with an overlaid median line and maybe box plot, it seems to be good to see differences in distribution. I guess a histogram looks a little less visually messy.

It's basically the same thing except the exact value can be shown in a swarm plot, instead of being put in bins of arbitrary width in a histogram. But swarm plots where the points are overlapping, like in this paper, don't seem as helpful because you can't see the distribution clearly.

The Groton Maze Learning task seemed to produce the largest differences in this study. A while ago, I wanted to see if I might be able to do the task myself somehow on a regular basis to track cognition. I couldn't find any sources where it was freely available, so I tried to piece the...

Yeah, I like that idea. Any idea why the digit span plot doesn't include the more recent MCAM study (Lange 2024)? I haven't looked at it in a while, but it was pretty large and seems to have included backwards digit span tests which were non-significant.

Thanks @ME/CFS Science Blog for the quick summary on Bluesky. The nearly consistent direction of effect in the plots is interesting.

My guess is that all the points with identical values were below the limit of detection, and were just given an abitrary low value. That might be what this sentence is talking about: Edit: Though that doesn't explain why some points are also below this value, and one is even at 0.

I'm not a fan of the overlapping points here making it hard to see exactly how many there are. But otherwise these types of plots are very common in papers on biological markers. As far as I can recall, histograms are rarely used for something like comparing cell counts.

I feel like I'm missing something. Is Uplinza funding separate from the National Decade against Post-Infectious Diseases? From the linked page: From previous post:

Wow, an article about your blog from ME Research UK. Congratulations! ME Research UK: 'The “most interesting ME/CFS research studies of the year” included work from the DecodeME team, Assistant Professor Rob Wüst, Dr Bupesh Prusty, Dr Nuno Sepúlveda, and Professor Carmen Schiebenbogen

Why a red flag if they're studying patients with fatigue-associated long COVID, not necessarily PEM LC? My understanding/sense is that there are many with fatigue due to LC but they don't necessarily have PEM.

For some reason, this was posted to a different preprint server. The only substantive change to the abstract was replacing "PASC" with "long COVID". And the author list looks slightly different. Persistent Immune Dysregulation during Long COVID is Manifested in Antibodies Targeting Envelope and...

REGENECYTE cord blood cell therapy in post-COVID syndrome: a phase IIa randomized, placebo-controlled trial [Line breaks added] Background Post-COVID syndrome affects a substantial proportion of individuals worldwide and imposes significant healthcare and economic burdens. Fatigue is one of...

Table 5: It looks like alleles of this haplotype increase risk of neuropathies. This is the same haplotype that looked to be protective against ME/CFS in Lande 2020, with supporting evidence from other studies:

Also DecodeME. While it didn't quite reach the genome-wide significance threshold, it had a p-value of 2.48x10-7, so there's still a good chance it's a real finding. The locus can be seen in this post.

Yeah. Well more specifically no genetic difference in this cohort. It could still be involved without having significant mutations.

It doesn't appear to be:

The whole concept of ME/CFS seems less helpful to me as a whole than just the concept of PEM. ME/CFS seems like a bunch of random symptoms put together because they seem to somewhat occur together and which help put people in boxes at the doctor's office. And even with this ME/CFS diagnosis...