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Insights into the Complex Biological Network Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome [Line breaks added] Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder characterized by immune dysregulation, metabolic...

Several posts have been deleted that linked to now deleted social media posts.

To clarify, Dr. Alberts appears to be a real doctor, while the Twitter account was likely someone impersonating him, and it's now been deleted.

One thing I'm not sure about is whether testing for the newly added 108 participants was done totally separately from the original 37 from the last study. They say everyone from that last study was ill for up to 179 days ago at the time of testing: So they would all be in the <200 group, and...

After seeing the data and seeing that these metrics seemed to be worse in people who had been ill longer, they decided to split into two groups to see what the difference between the two groups might be. They chose 200 days because it splits them cleanly into two groups by their calculated...

Hmm, that's confusing. The paper points to Supplementary Table 7: But the table doesn't include any of these three that they say are most significant: Colorectal cancer is most significant, as suggested by the plot above. So I think they looked at the top three terms in their plot above...

PDK4 and PDHA1 were upregulated in the tissues exposed to ME/CFS serum in this study: They were also upregulated in another study: Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome, 2016, Fluge et al Though PDK4 was...

Main points: The recently posted study is just meant to determine the best dose for a future larger efficacy trial. It's not yet recruiting or funded. Posting the protocol was the first step in the process to get funding.

There is a follow-up to this study: Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue (2025, Germann et al, Preprint)

They combined data from two groups of people with post-COVID fatigue. A group of 37 that they analyzed previously, plus data for another group of 108 patients. Here are the threads for the previous studies (refs 15, 16): - Neural dysregulation in post-COVID fatigue 2023 Baker et al - Recovery...

This looks pretty interesting because they tested a lot of different objective nervous system metrics. I don't know much about these measures, but there's measurements related to things like reaction time, cortical excitability, blood oxygen saturation, and peripheral fatigue. Some examples...

Evidence of Accumulating Neurophysiologic Dysfunction in Persistent Post-COVID Fatigue [Line breaks added] Abstract A major consequence of the COVID-19 pandemic has been the emergence of post-COVID syndrome (PCS), and more specifically, post-COVID fatigue (pCF), with an estimated prevalence...

I don't know much either, but I thought there was a way to filter molecules by size. So you'd split patient serum into large molecules and small molecules, and see which of these still has an effect on the muscle like in this study. Then split the one that does by size again and try again. It...

I took a long break from adding studies to my app after I let perfect become the enemy of good, and became overwhelmed and overworked. Basically, I was trying to create an all encompassing criteria that could apply to every study I came across, and as you can see it was getting quite...

Note that we have a thread for this article: Brunel University London - Reactivation of herpesviruses in Chronic Fatigue Syndrome

The IOM criteria, which many studies, including DecodeME, use, doesn't require a flu-like feeling. From DecodeME: Edit: The criteria from the NICE 2021 guidelines doesn't require flu-like feelings either.

Distinct Symptom Clusters Reflect Pathophysiological Mechanisms in ME/CFS Habermann-Horstmeier, Lotte; Horstmeier, Lukas M. [Line breaks added] Introduction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystemic disease with a broad spectrum of symptoms. A...

I'm not sure I'm saying something different from you. All I meant was, for the specific phenomenom of PEM, with the characteristic delay and several days long crash which is weird and so far eludes explanation, it seems fairly likely to me that there's one specific process that causes this same...

I'm not at all confident enough to make any strong claims, but these are basically the vague ideas that float around in my head: Symptoms related to sickness response (similar to flu symptom mechanism) - Genetic studies pointing to brain (DecodeME, Zhang preprint on HEAL2 model), aligns with...

I contacted the authors who confirmed the figure was not correct, and I see that they've updated the figure: