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No spoons right now sorry.

What would this mean/entail? I think it was suggested the other day we need a new charity. If reforming AfME like JE has suggested isn't the way to go, then I think that person was right. It would be an unthinkable amount of work but a charity connected to S4ME that funded research that...

Thats fair. It took me a good while of scanning just to find participant numbers because its in the results! Surely that should be front and centre?

My first proper girlfriend in sixth form loved Ricky Gervais and I got dragged to two of his films. Not something I missed when we split up! He's had a few good standup shows, and extras and the office are good, but by and large he's a smug unfunny bully who hides behind an 'I'm just kidding'...

I couldn't say. In terms of benefit, I think the evidence for this JAK drug is a small case study (search the drug name on here to find it). I dont know anything about the other drug. These are serious drugs and only you can make the decision to participate. It depends on your personal...

https://www.sciencedirect.com/science/article/pii/S1359644625000881 Potentially relevant article from last year.

Does this sound plausible? @jnmaciuch @Jonathan Edwards

This looks potentially really interesting, will be interested to see full study.

Damn! Well, it was a nice thought while it lasted. Could you possibly expand on why?

That's a good point. Perhaps Ponting and Co could start some kind of outreach/ask around for one? Same with Altmanns team etc.

That's a fair point. But people on here will probably be able to figure out if tbe result is real.

From reading in the other thread it seems like she wants to do cd20 as well as cd19 and cd38 maybe? I mean at least we'll get some really concrete answers on that and put the rituximab debate to bed at last if they do that.

Apparently isa is funded too...

I'm not very optimistic for this trial in particular but this is very good news because the isatuximab trial was supposed to be a platform trial with a drug of this class so hopefully that will now go ahead as planned too! It looks like uplinza it works on cd19 not cd20 like rituximab...

I thought she already has pharma funding for isatuximab?

If it can be replicated, would that be enough evidence for a T cell drug trial?

As in the main pediatric team were complaining on bluesky beause they wanted psychatric services, or the project paediatric people wanted them?

Agreed, I think this is an unnecessarily strict constraint.

I don't know about this. Something like daratumumab working out could give a huge boost to the basic science. But that is already happening. I think there are a few things like T cell depletion that we are very close to being at the point where a therapeutic experiment is justified. At the same...

Could you expand on how one might do this? Thanks for your insightful replies in this thread btw!