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I think the ME/CFS study also looked at the CD16+ subset: The description of which lymphocytes were tested at baseline from the protocol:

There was discussion about NK cell counts correlating to response in multiple myeloma, with the caveat that I think those studies saw correlations based on bone marrow NK cells, as opposed to blood like in the Fluge study. -...

I think it's that first each metric is considered a separate experiment with a threshold of p<.05 for the ANOVA comparing all groups at once. Then for each metric, they do 3 pairwise tests: ME/CFS-LC, ME/CFS-HC, LC-HC, so they divide the threshold by 3 to account for this. But no multiple test...

Without any healthy controls, I don't see how we can have any idea that any of this is specific to long COVID, and not just an effect of exercise.

It's a bit strange to me how consistent the results are for all five of the miRNAs they tested: They seem to have used something called fractional rank as a measure of miRNA levels. So they determine, for each participant, the rank of each miRNA. If a given miRNA species is the 25th...

Good point. Comes across a bit as just a call for donations, which people might instinctually ignore, as opposed to an informational message.

"Us" in line three is referring to everyone trying to find an answer. "Support" is ambiguous if the second part isn't just about pwME. The support a researcher, or even a caregiver, needs is very unlike the support a bedbound patient needs, so I think the sentence would be too confusing with...

Maybe we could make an S4ME branded meme/image for sharing on social media. The message seems impactful and gets across both the problem of ME/CFS and what S4ME is focused on. With slight change from: To "We" doesn't seem like it would work when talking about S4ME because there are people...

Exploring the effects of GLP-1 receptor agonists in fibromyalgia: a propensity-matched real-world cohort using TriNetX research platform Nouran Eshak, Anushka Irani, Megan Sullivan [Line breaks added] Objectives We aimed to evaluate the effects of GLP-1 receptor agonists (GLP-1RA) on symptom...

Response to the Comment by Steinkirchner et al. On the Article “Variation in Repeated Handgrip Strength Testing Indicates Submaximal Force Production in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome” Stoyan Popkirov See article for full response. Web | PDF

Comment on “Variation in Repeated Handgrip Strength Testing Indicates Submaximal Force Production in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome” Felix Steinkirchner, Viktoria Kimmerling, Christina Kaufmann, Elisabeth Schieffer, Michael Gruber, Alexander Dejaco See...

Thread about paper for recovery rate in children and a bit of speculating similar to this thread: Long Term Follow up of Young People With Chronic Fatigue Syndrome Attending a Pediatric Outpatient Service, 2019, Rowe

Oh ok, thank you. I think I would personally be much more annoyed at having to take pills four or more times a day than just sipping from a water bottle throughout the day, which I do anyway.

It looks like they used data for controls from a previous study: S4ME From that paper:

I'm not arguing for adopting CPET as an endpoint, but I'm not sure I understand your specific point here. Presumably, a decrease in metrics on day 2 is not analogous to weak grip strength, since the idea is that this is not something seen in deconditioning, so exercise alone should not improve...

Could you say this in a different way? I'm having trouble following.

Identifying interventions and coping strategies to address the psychosocial repercussions of long-COVID: A qualitative interpretive meta-synthesis (QIMS) [Line breaks added] Abstract Long-COVID is a serious public health concern impacting millions of adults and children around the world...

Olfactory Dysfunction and Cognitive Deterioration in Long COVID: Pathomechanisms and Clinical Implications in Development of Alzheimer’s Disease Abstract Complete or partial loss of smell (anosmia), sometimes in association with distorted olfactory perceptions (parosmia), is a common...

Longitudinal Landscape of Long Flu and Long COVID Zheng, Ming [Line breaks added] Abstract Influenza is typically framed as an acute respiratory infection, yet accumulating evidence suggests that—like SARS-CoV-2—it may trigger persistent, multi-organ morbidity consistent with a post-acute...

Graph-Neural-Network-Based Brain Connectivity Analysis for Early Detection of Long-COVID Cognitive Impairments Using MRI/fMRI Dubey, Supriya; Singh, Jitendra; Bhardwaj, Manish [Line breaks added] Abstract Long-term COVID are frequently causing neurological problems that persist for long time...