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I think the IoM report may have used similar language in that they were saying a diagnosis is due to the characteristics in the criterial (things like PEM) (perhaps with suitable exclusions) rather than because other causes can't be found.

Wasn't he on the first Nice GDG (the 2007 one)

The HRA isn't an audit body in that it doesn't actually do checks. They expect certain documentation to be sent and check it ticks their boxes. An auditor would go in and demand access to all the information and select randomly from that to look for evidence that what is being claimed is...

We can give a strong message that if GRADE finds (or allows some to find) that what are really poor quality trials (with measurements that are highly subject to bias and a lack of control for different expectiations) then it does not mean that the trials provide moderate evidence but that GRADE...

I'm not sure if this is related to long covid but thought this tweet was interesting. It is refering to data from the UK labour force survey and is pointing out a rise of about 150,000 people who are economically inactive due to long term health problems (from dec-feb 2020 to July-Sept 2021...

I think that is clear in their comments to NICE. Although I wonder if there is some cognitive dissonance which doesn't allow them to grasp that their work is not up to standard - that is quite natural for individual researchers but that is where there needs to be good governance processes and...

There is a difference between oversight and audit. Audit (or at least form the perspective of the auditors I've worked with) involves looking at two things - firstly are the defined processes and proceedures being followed and in the case of a trial I expect that would be is the protocol and any...

Its interesting looking at this from the perspecitive of different disaplins. As someone who works in security we do reviews of systems to try to spot potential failings and security issues but I think more importantly try to build methodology and tools into the standard processes in order to...

The sampling issues can be worse if they are just using 23andME which is a paid for service. I thought there were some accuracy issues with it as a service as well.

I think this may be a key point. What is probably more interesting is what mechanisms the genes are involved in. For example NCAM1:NCAM1 neural cell adhesion molecule 1 [Homo sapiens (human)] - Gene - NCBI (nih.gov)

Yes its one of the reasons that 'clinical experience' can be very dodgy for trying to form any sort of evidence base. Yet this is what the RCs seem to believe is the right approach as 'the doctor is always right' in their view.

There is a different conclusion which is that they don't follow up so they don't see harm because they cover their eyes and look the other way. The problem becomes one of whether therapists acknowlegde harm (and if a protocol says symptoms can worsen initially then perhaps they effectively...

The GRADE process and systematic review is done by a technical team not the committee but the committee provide some guidance.

It may be a case of getting someone to add better search terms. But I agree understanding the process that photo editors go through to select a photo is essential

It can even be cheaper than using free photos where they would need to spend time checking out a license wo it seems important to get the right pictures in the repositories they use.

There is an issue in that I've not mapped s4me.info to www.s4me.info. So they are different URLs and recognize as such by browsers (having realized I hadn't done this originally I decided not to since it could cause people some password issues (depending on how browsers remember passwords).

I think that is really important and will probably need tobe highlighted multiple times.

I think there is always a trade-off between doing things like this or not. One of the points made was around it help in arguing for more money from the research councils who take the output seriously (hence worth doing). But there is always the danger that bad research will be the outcome (or at...

I think with John Prescott they always went through an editing process to make the meaning clear.

I think some people still do (its still used)- just not pregnant women.