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This website ranks AUC (area under the curve) scores like this: ( a score of .50 is like a coin toss ) .90-1 = excellent (A) .80-.90 = good (B) .70-.80 = fair (C) .60-.70 = poor (D) .50-.60 = fail (F) [This table also shows up in this 2009 paper on diagnostic accuracy. ] I've also seen it...

Sort of along the same lines, I noticed that ceramides were mentioned, but only becasue I first heard of ceramides last winter when my dermatologist prescribed a ceramide-based cream for my hands that were chapped to the point of bleeding. Ceramides are a waxy lipid molecule that help to retain...

Not that I claim to fully understand this, but I think a major take-a-way here is to be found in chart S3 in the Supplementary Figures & Tables. They take their previous work on bacteria and combine it with the top 10 predictive metabolites found in this study and find that they can...

He does not specifically mention burning sensations in the video. When he mentioned that small-fiber polyneuropathy was being found in skin biopsies of 40% of ME patients who also had "pre-load failure," and then mentioned that those fibers can produce "neuropathic pain" when they are misfiring...

Interesting. I've never really paid much attention to "small-fiber neuropathy," considering it to be connected to fibromyaglia, which I assumed was mostly diagnosed by tender points, which I do not have. However, I have experienced unexplained, and very long-lived sunburn-like sensations on/in...

Interesting article on how the cytomegalovirus (CMV) evades the immune system. It prevents the infected cell's MHC (HLA) molecules from reaching the surface of the cell, where they would normally prompt the immune system to destroy the cell. However, the absence of MHC molecules on the cell's...

This somehow reminds of the time that talk show host David Letterman became irate when his attempt to replicate the "Denorex Challenge" was interrupted. He loudly insisted, "This is SCIENCE, damn it!"

Leonard Jason is at DePaul University in Chicago, Illinois. Chicago apparently uses a version of "The Philadelphia Grid System," in which there are 8 blocks to a mile. So, if that's the metric - and I'm not sure that it is - a block would be 660 feet long. "A walk around the (square) block"...

God, what an awful article. Opinions expressed by Forbin are his own. [ Of course, I probably didn't take the time to understand it fully - which only seems fair. ]

Makes sense. The article I linked above also says, "Absolute ethanol may inactivate microbes without destroying them because the alcohol is unable to fully permeate the microbe's membrane." I don't know why diluted alcohol would more readily cross a membrane, though.

According to Wikipedia, ethanol's optimum concentration when used as an antiseptic is 70%. Vodka is typically 40% ethanol, so not the best antiseptic, but probably better than nothing. Some vodka ranges higher, with a theoretical maximum of 95.6% ethanol by distillation. Vodka in the highest...

It sounds like these would be non-living, t-cell-sized, flexible capsules with a surface coating that makes them stick to infected cells. I guess the interior of the capsule would contain some sort of cytotoxic substance that would somehow get released when contact is made. Sounds like they've...

According to Cort's article about this on his website ( https://www.healthrising.org/blog/2018/06/25/davis-nih-grant-chronic-fatigue-syndrome/), it seems that this was the first of Ron Davis' applications to go through a "special emphasis" review panel for ME/CFS.

Yes, I noticed that between "Autoimmunity" and "Autoreactivity" they wedged in "Automobile Driving." :confused: [Fantastic news BTW!]

Sounds somewhat like, believe it or not... "Exploding Head Syndrome." What you describe sounds like a more complex sound, so it might not be EHS. I experienced something along these lines once or twice about a decade ago. It was like waking up hearing a loud "crack" that seemed to come from...

I believe the 2-Day CPET test was mentioned at the hearing today. Replicating that and determining how specific that test is to ME would be of great value. The BPS explanation is in doubt. Confirming the diagnostic validity of 2-Day CPET might shovel the deconditioning theory into its grave...

In this 1996 paper by Sharpe, et al., Cognitive behaviour therapy for the chronic fatigue syndrome: a randomised controlled trial, they say: I'm hard pressed to think to of something that is "inaccurate" yet "true." Common synonyms are "erroneous," "fallacious," "incorrect," "wrong," and yes...

I like to think that I know good writing. That was good writing. :thumbup:

The one that begins with "First, do no harm."

It might go back to here (1998), though the word "false" is not used. I can only see the abstract. ETA: RE: "than has been previously thought..." The above assertion that causal beliefs do not affect outcomes (as opposed to beliefs about exercise/activity) runs contrary to a LOT of prior...