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The first one I found on a quick scan papers here was Risks of digestive diseases in long COVID: evidence from a population-based cohort study, 2024, Yuying Ma et al Because they are close, I tend to look at long covid studies. My suggestion is simply that since there are enough interesting...

For the past 20 years "needing to lie flat" has been my mantra I've been taking high blood pressure medication for many years. Recently I discovered that without blood pressure medication I'm 120/80 most of the time lying down, but 150/100 pretty much all the time I'm upright. I've said for...

There has already been a lot of discussion about "sickness response", Dauer, etc. You've asked the pertinent question. Is there a feedback loop that keeps the body in a sickness state? What if the body becomes sensitized to the presence of a particular toxin? Gall bladder dysfunction is common...

CYP3A4 Here is a candidate that fits the “virus attack followed by long term inflammatory response". CYP3A4 is the most abundant liver enzyme affecting a very wide class of drugs. During a viral attack, the levels of CYP3A4 are significantly downregulated. There is an interaction with the...

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.791922/full Coronavirus disease 2019 (COVID-19) has become a new public health crisis threatening the world. Dysregulated immune responses are the most striking pathophysiological features of patients with severe...

https://www.mdpi.com/2227-9059/10/11/2686 Abstract: CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous...

Nailfold issues are common in scleroderma, where Raynaud's is also very common. There is some good information about techniques in this article https://pmc.ncbi.nlm.nih.gov/articles/PMC8922564/

It is my own thoughts from my own experience. I hope I got it in a correct section. Normally I have a more terse and folksy writing style. I wasn't attempting to deceive, but to put it into a more clinical language rather than relating my own experience.

Hypothesis In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-Acute Sequelae of SARS-CoV-2 infection (long Covid), endothelial dysfunction is posited to compromise the glomerular filtration apparatus, leading to a renal response characterized by elevated renin secretion...

When homosexuality was in the DSM there was gay conversion therapy and the hunt for the gay gene so homosexuality could be fixed or eradicated. Physical and mental health problems were used as a reason for fixing rather than being a result of the pressures of being in the closet. When it was...

Here is a link to an explanatory article https://scitechdaily.com/the-hidden-heroes-of-your-cells-how-mitochondria-balance-energy-and-survival/ I wonder if the researchers works be able to measure the mitochondrial subtypes in ME/CFS. It would be interesting to see the state of the energy...

Histamines and inflammatory (ctyokine) processes are related. At one time Dr. Bruce Patterson was working really hard at tamping down inflammatory cytokines in COVID and ME/CFS. My feeling is the approach helps symptoms in the short term, but in the long term a different inflammatory process...

I'm in my 60's and have had ME/CFS forever. As a child my nickname was "Disgustingly healthy". There certainly weren't any issues with allergies or anything allergy related. In the last 5 years Mast cell symptoms that have been reduced by reducing histamines and taking twice daily...

I get very small spasms on my calf muscles, much like there is something moving under the skin. They aren't really even noticeable unless I happen to be wearing shorts. Way back 10 years ago these "fasiculations" were often listed as an ME/CFS symptom. My least favorite medical words are...

There is nothing in the document regarding "I just have to lie down" orthostatic intolerance. That is, without tachycardia or fainting. It would be nice to see treatment plans separated for all three.

I'm an autistic gay man with ME/CFS whose insurance company used "damned if you do", cut you off, approach to force me into GET because "I wasn't trying hard enough". Their big pitch to sell it was that they weren't trying to get me back to work, just help me feel better. My earliest childhood...

There are two things I really appreciate about this forum. First is the critical and science based approach. Second is the knowledge, experience and expertise of many of the participants.

"Key Facts Ketone bodies directly bind to misfolded proteins, enhancing their clearance via autophagy. Mice treated with ketone esters displayed reduced aggregation of insoluble brain proteins. Similar metabolites tested showed effects equal to or better than β-hydroxybutyrate."...

"Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). We identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility. βHB primarily provides ATP substrate during periods of reduced glucose availability, and regulates other cellular processes through...

It was about seven years ago. There wasn't other testing so it was the best available. I seem to recall starting the process by sending them information from Bateman Horne and they said they could do the same tests It was sports fitness testing at an educational facility that did testing of...