Search results

Interestingly, the authors of this letter — including Wessely — blamed NICE for not using long-term follow-up data (1 to 2 years post-treatment) in the depression guideline, but Wessely, White and co-authors are now blaming NICE for using the longest available follow-up data for the PACE trial...

Exercise exerts a wide range of beneficial effects for healthy physiology1. However, the mechanisms regulating an individual’s motivation to engage in physical activity remain incompletely understood. An important factor stimulating the engagement in both competitive and recreational exercise...

Known methodological issues such as publication bias, questionable research practices and studies with underpowered designs are known to decrease the replicability of study findings. The presence of such issues has been widely established across different research fields, especially in...

In my view, White reached out to Stone and Carson, both of whom are editors of the JNNP and leaders of the FND movement, so that he could publish his manifesto there, and in turn Stone and Carson reached out to other FND influencers (possibly via a mailing list). I am not sure that there is...

The author of the email is said to be Wessely, judging by the typos in his texts that matched those in his tweets.

PACE trial investigators Brian Angus Trudie Chalder Maurice Murphy Michael Sharpe Peter White COFFI committee members Dedra Buchwald Trudie Chalder Daniel J Clauw Paul Garner Andrew Lloyd Jos WM van der Meer Simon Wessely Vegard Wyller

Breakdown of authors by specialty and area of research. Only academic affiliations are given, except for clinicians who do not have one. 11 countries are represented. Below is the tally by country. 1. UK: 28 2. USA: 7 3. AU: 3 4. CA, DE, NL, NO: 2 5. CZ, DK, FR, IT: 1 Psychiatrists &...

Some of the “errors” that the authors mention are outright misleading. I am puzzled by this argument. The 2007 NICE guideline (CG53) already required post-exertional fatigue or malaise with the typical 24h delay and prolonged recovery (§1.2.1.2). It also states that the diagnosis of CFS/ME...

Alyssa, who is 13 and from Leicester, was diagnosed with T-cell acute lymphoblastic leukaemia in May last year. (…) Base editing allows scientists to zoom to a precise part of the genetic code and then alter the molecular structure of just one base, converting it into another and changing the...

These honest researchers would not lie, surely?

I find it very problematic that Dr Systrom continues to tout Mestinon as an effective treatment against post-exertional malaise (specifically) despite his trial showing no clinically meaningful difference on the invasive CPET between the placebo and Mestinon arms.

All of the NIH research staff, like Avi Nath and Wallitt involved them in the intramural study (according to Brian Vastag, 79 authors are listed on the submitted article). Unless the pathophysiology of ME/CFS is better understood and, specifically, pinpointed to a certain biological mechanism...

Virtually all the statistical methods researchers commonly use to assess genetic correlations assume that mating is random. That is, they assume that potential mating partners decide who they will have children with based on a roll of the dice. In reality, many factors likely influence who mates...

A new mission for Dr Gerada, surely.

It seems to me that, at least lately, very few (if any) biomedical research articles on ME/CFS have been published. I am not sure what to put it down to other than 1) investigators were not able to collect biological samples from ME/CFS patients in 2020 and 2021 because of the pandemic and 2)...

This protocol does not make sense. The authors say that the study ran from September 2021 to September 2022, but they are only publishing the protocol now. Yet, they write: “The study will be conducted in centers or hospitals worldwide after getting the Institutional Review Board worldwide by...

The DePaul PEM questionnaire has its flaws but it is interesting to see that, overall, twice as many test-positive participants met the IOM criteria (1.1% vs 0.5%) considering that the incidence of CFS up to two years after the swine flu pandemic was doubled in non-vaccinated vs vaccinated...

Cronbach and Meehl (1955) introduced the concept of construct validity and described how researchers can demonstrate that their measures have construct validity. Although the term construct validity is widely used, few researchers follow Cronbach and Meehl’s recommendation to quantify construct...

Of note: “We found no correlation with MoCA subscores and saccadic performance, possibly due to a ceiling effect. The MoCA is a rapid cognitive screening tool, and our patients had normal scores.” The MoCA is the Montreal Cognitive Assessment test. A limitation of the study is that...