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Increasing evidence suggests persistent cognitive dysfunction after COVID-19. In this cross-sectional study, frontal lobe function was assessed 12 months after the acute phase of the disease, using tailored eye tracking assessments. Individuals who recovered from COVID-19 made significantly...

I also came across this: https://med-mastodon.com/@CastlTrAstonDrs/109313935213337419 “#Neurology Increasing evidence suggests persistent cognitive dysfunction #LongCovid .In this cross-sectional study, frontal lobe function was assessed 12 months after the acute phase of the disease, using...

Two interesting parts in the article above: “extremely large effect sizes at both short and long-term follow up, (which is something that is really not common in the field of chronic pain and certainly not seen in other trials of CBT),” — Neil O’Connell, coordinating editor for the Cochrane...

The duration of testing is essential. We have seen multiple long Covid studies where two or three short tests from the NIH toolbox were used and revealed no cognitive impairment. In Norway, Wyller recently published a similar study in teenagers with ME/CFS. My neuropsychological (cognitive)...

Epidemiological studies are indeed paramount to better understanding ME/CFS and emphasizing its scale at a societal level. However, once the results are in, they must be acted on and this requires the involvement of politicians. It would seem wise to set aside some money for political lobbying...

Note that if one outlier is removed from the results, they are no longer significant:

Vogt’s response is truly strange. What is Recovery Norway other than a movement, given their lobbying activities? He would be very quick to label the Norwegian ME association as such, but it seems he has double standards. RN may not be a wealthy organization, but it has been funded enough to...

Yet another study showing that the SF-36 physical function questionnaire threshold of 60 in the PACE trial is indefensible. Subtracting one standard deviation from the mean of the healthy group yields 85.5 as the recovery score.

“Patients will be selected using the Oxford diagnostic criteria for CFS…” Truly a PACE 2.0.

We discussed the 80% threshold a few pages back — I believe it was @Pustekuchen who showed that IQWiG followed their methodological guideline and did not arbitrarily choose the 80% inclusion threshold.

It is pleasantly surprising to see such an editorial in a Lancet journal (The Lancet Regional Health — Europe).

I imagine that we should be aware of B12 deficiency in ME/CFS by now if it were a problem. However, given that it can cause anemia and thus profound fatigue, it may not be surprising to see people with B12 deficiency misdiagnosed with ME/CFS if they have not been tested for it. Additionally, I...

Perhaps the most important aspect of this article is that Dr Bik explained the background context which incites researchers to cheat in simple terms. If someone were not aware of the problems with academia, I would direct them towards this article.

One of the authors made this point: “Mind” in this work is presumably to be understood as “planning voluntary movement”.

Surely, textbook rewrite worthy discoveries such as this work (Penfield’s motor homonculus model dates from 1948) should prompt neurologists and psychiatrists to remain humble about our limited knowledge of the brain.

Primary motor cortex (M1) has been thought to form a continuous somatotopic homunculus extending down precentral gyrus from foot to face representations. The motor homunculus has remained a textbook pillar of functional neuroanatomy, despite evidence for concentric functional zones and maps of...

I am not aware of any such research, but like other infectious diseases, tonsillitis, appendicitis and cholecystitis caused by pathogens may well trigger ME. As for the appendix, I have anecdotally heard that it serves as a reservoir of good bacteria for the gut. I do not know whether this is...

I talked briefly with a clinical lead consultant in allergology and expert for the French Health and Food Security Agency. He mentioned that he has seen about 10 cases of MCAS in almost 3 decades (as diagnosed by serum tryptase and urinary metabolites of histamine, i.e. as per the AAAAI /...

In essence, this consensus statement (which mostly included clinicians and few researchers) is a rebuttal of the restrictive “consensus-1” diagnostic criteria that were established by mastocytosis experts (Valent et al 2010), which are as follows per their 2019 update: The authors mainly...