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I wasn't aware it came directly from the Vice Chancellor. That puts him in a difficult position in the long term because what he has done there fails basic ethical tests (certainly any headline test). It is something that eventually could stick to him and destroy his reputation for a long time...

To me its less the authors who should face consequences and more those who failed to apply a level of governance. So for example the head of QMUL who failed to ask questions and spend a lot of money trying to cover up the results. Or the Vice Chancellor of Bristol university who has failed to...

So what is a pragmatic trial?

So the impression I get from your paper (which could be wrong I only read it quickly) is that you gave a supplement to a number of patients with a disease that is varies over time and then sorted the patients into those who improved in a given time period and those who didn't. It seems hard to...

I think its something to do with the maximum likelihood optimization over what are assumed to be probabilities using the cost function: J(θ)=−∑i(y(i)log(hθ(x(i)))+(1−y(i))log(1−hθ(x(i)))) With y(i) being the target ith training sample and x(i) being the input for the ith training example and hθ...

So I would come back to my question of why the output of a logistic regression would be a probability? Does it meet the basic axioms. My assumption is not but i've not looked into it. I did read about logistic regression a few years ago and it seemed to be similar to a single layered neural...

Why do you believe p is a probability because if scales between 0 and 1. I don't really understand how your paper got published. You seem to have shown that you can train a model on data to discriminate between two classes but that is not hard. I can do that with random data that I allocate...

Making it a number between 0 and 1 doesn't make it a probability just a number between 0 and 1. But that is likely to be the reasoning. In neural networks the logistic function is used to introduce a non-linearity and also limit the output to between 0 and 1 although these days I think a...

But there is a serious question as to whether this is a valid operation. The FSS scores are basically just answers to a random set of questions vaguely about fatigue. Is it valid to add them up and average? What is the meaning? I also don't get the rational for using the logistic function and...

I don't think its always about shaming the poor sometimes I think its about the rich trying to justify why they are entitled to be rich and pretending its deserved rather than an accident of birth.

To me its that they create layers of abstractions that are not valid or not valid to use under certain circumstances but because they've created that abstraction they forget. So they have a set of questions and call is a depression scale and then use that abstraction of the depression scale as...

The problem with some studies is that they use questionnaire where the questions are not designed to separate not being able to do stuff from not wanting to do stuff. So things like HADS is bad at this. It has the depression quesions So the ones I've bolded could be due to illness or being...

I think he is just keeping us informed of what is out there.

This is one of the really frustrating things. By hounding families whose children have ME there is an opportunity cost around not helping others who need help.

I think that is one of the things they have relied on. A slight nudge to other academics to be quiet and to not knock the boat. Also behind the scene nudges to journalists. I think they way the medical community has backed bad research and failed to act is one of the big scandals around PACE...

The service is RUH Bath (i.e. the hospital trust) not the university. Crawley works for Bristol University. In general I'm not impressed with the letter. I think if someone didn't understand the issues then they wouldn't get much from reading this. I also object to the ME isn't CFS as there is...

They claim that in trials GET does no harm but most trials didn't bother to look. PACE was relatively good in that it did look but I think they changed there definition of serious deterioration in the Lancet paper from the full protocol. It was hard to meet because the deterioration needed to be...

I think these stories are far too common. My father new someone who was told he had stress headaches but it was too late when it turned out to be a brain tumor. Doctors are encouraged to dismiss patients these days as the worried well. I don't know what the motivations have been in the past...

I suspect they did two different analyses one with men and women and a different one looking for correlations with income so they may not have explored the relationship. Then the journalist combines these in a single sentence. It would be interesting to know what else they looked at (say age...

(Sorry a long complex question) I have a question around collecting, testing and interpreting samples. ME becomes worse with exertion and this can last multiple days. Should we therefore consider the body as a dynamic system when taking samples and thus always take them with an understanding...