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Elevated blood B6 without supplementation suggests there is a problem getting the B6 into cells. I haven't seen any research on this, apart from studies of very serious in born errors of metabolism, where for example, in the condition hyphosphatasia, there is elevated serum B6. The reason for...

I wasn’t sure where to put this. It is general background information about metabolism, but since it is directly relevant to energy production in PWME and hence fatigue, I put it here. Recently I needed to refresh my memory about how some amino acids are broken down for energy. I thought I...

My understanding is that there is no consensus that there is low NK cell activity in PWME. There have been too many inconsistencies and failures to replicate results. I believe there is an international study which is trying to replicate results but really I am not up with the latest...

I don't know of any that hold up. I don't think the studies that Lassesen relies on mean much since the technique used for studying bacterial composition is unable to detect most species. Basically it is a culture based test which is heavily biassed towards anaerobes and species that can be...

I can't help with testing for MMA and homocysteine in the UK (in Australia I can get those and active B12 tested free on the NHS) but I do know a bit about B12 so can comment on some of the aspects you raise. I couldn't find anything about the significance of high active B12 as a percentage of...

Could be - I have always been a morning person.

When these types of association studies first started appearing the concept and the analytical techniques required were sufficiently novel that they could stand alone. The techniques are now in widespread use and there are many studies in an increasing number of conditions showing changes in...

I've not looked at that page before. It does repeat a number of Yasko's errors.

I picked the first option. My very best time is for 3-4 hours after waking up. Middle of the day and early afternoon is the worst. I usually get a bit of a boost late afternoon/evening but nowhere near as much as in the morning.

Methylation is about the transfer of single carbon units (methyl groups) which are used in a wide variety of biosynthetic processes in the body. At the heart of 1C transfer is the folate cycle which mediates three biosynthetic pathways, de novo synthesis of purines, thymidylate synthesis and...

I don't think those categories are fixed - I used to fit in the former but am now in the latter. Improvements in digestion and in microbiota composition (which I have followed with uBiome tests) haven't affected my illness either. This doesn't mean there is no influence of the microbiome but...

I picked the second option. Have only had one remission. The relapse was worse than the original illness and I'm slowly getting worse. Whether there will ever be another remission who would know? And yes how to distinguish getting worse from the disease and the consequences of sedentary...

There is a significant amount of the hydroxy form in foods, probably as the result of breakdown of the active forms from exposure to light, but there is about as much in the adenosyl form. Some foods have significant amounts of the methyl form. See this paper. In the body adenosyl is the...

Probiotics are live bacteria which do seem to have various beneficial effects as they transit through the gut, though for the most part they don't actually colonise the gut. Prebiotics are food for colonic bacteria, components of food we eat which we can't digest but our gut bacteria can...

Yes if not listed it's not there or present at such a low level that it was missed in sampling. I used to be very keen on FMT, now that I've seen what is actually in my gut I am not so sure. I don't think my gut is so bad (your's has a lot of similarities to mine) and while it could do with...

The authors seem to have done quite a bit of work on GWI and so probably feel more comfortable making comments about possible mechanisms in GWI, but I don't think these results say anything yet about pathophysiology. At best they give hints about areas which would be worth further investigation...

Fructans are simply short chains of fructose molecules and are one type of FODMAP. The article claims they are difficult to digest. Actually we can't digest them at all, we are not meant to digest them. They are important food for our colonic bacteria and we should be seeking them out. Problems...

Anyone can order an OAT test from GPL. It costs of course.

Oxalates don't appear in urine only as calcium or magnesium crystals. A number of OAT tests look for oxalates but only one, from Great Plains Laboratory, looks at two other metabolites, glyceric and glycolic acids, which give insight into possible endogenous oxalate production. Oxalate...

Prevotella tends to be high with high carbohydrate diets, especially high grain, presumably reflecting its capacity to digest complex polysaccharides, particularly xylans which are high in grains. The genus tends to have an inverse relationship to Bacteroides; ie one or the others tends to be...