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    ME Epidemiology - prevalence and peak ages of onset

    I wish I had a clue. Flinging a few things in perhaps testosterone drops off a cliff for some rather than starts gradually. That the lack of cholesterol in diets precludes productions of sufficient pregnenolone Impact of pesticides on hormonal synthesis - most pesticide safety use...
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    ME Epidemiology - prevalence and peak ages of onset

    Testosterone starts dropping in 30s. Same biochemical impacts hold re synthesis pathways, cofactors and deficiencies. Perhaps the low cholesterol diet is responsible for other impacts other than the rise of T2 diabetes.
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    MicroRNAs as biomarkers of pain intensity in patients with chronic fatigue syndrome. Al-Rawaf (2019)

    I would agree I would agree re pain tolerance. My daughter finds it difficult to compare pain / " meh face" scores on a diary app she has as her pain tolerance has changed over time, probably as the nature and degree of pain has changed. People become accustomed to a background pain level...
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    ME Epidemiology - prevalence and peak ages of onset

    I know I do not have a science back ground but HORMONES!!! Puberty and pregnancy have huge hormonal shifts which also require co factors, pathways etc. Perimenopause can also start in 30s with shifts in estrogen production. Iodine deficiency is seemingly common, B12 and magnesium are required...
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    Want to learn about neurology

    When I jumped in at the deep end for uni a few years ago, I tackled the module I would have felt least confident with ( electrical systems) on the basis if I passed that I would cope (!) I used YouTube and Kahn Academy for a lot if the basics as I found 10 min videos were ideal for me in "...
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    Introducing #MEAction’s 2019 ME Research Summary

    I think my point is more re research in general. Chris Ponting only got a hit on a specific non hereditary gene as he looked at females only - within a mixed cohort it would perhaps never have been identified. I think there is the potential for more differences. Given differences in immune...
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    Blood volume and red blood cell volume in ME/CFS

    Given the different manifestations between Male and female from recent metabolonic/ protoeiomic studies, is there a way to break down research by gender? It may just throw up something?
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    Michael Sharpe: Mind, Medicine and Morals: A Tale of Two Illnesses (2019) BMJ blog - and published responses

    Is this simply to expand a fan base; we seem to be moving forward on basis of a personality cult.
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    Physios for ME

    Sadly our referral was for GET. Physio was nice but simply did not have a clue. Completely unrealistic prognosis and conflation with chronic fatigue. No knowledge of OI, low blood volume, comorbidities. I really hope that you can turn things around. My daughter would benefit hugely from...
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    Autism and ME/CFS

    ADD is slightly different from ADHD ( doesn't t have the hyperactive part, if anything less active and engaged). A friend's daughter was recently diagnosed at 21 with ADD. Noone picked up on it. Idiosyncracies were simply out down to her personality until she could not cope at uni.
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    Autism and ME/CFS

    You can epigenetically switch things off / on . Perhaps this is what is suggested?
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    Cognitive Behavioral Therapy "Evidence-Base" Is Exaggerated (Psychology Today)

    perhaps the reason that the CBT for the elderly did not have a befriending comparator group? lonliness in the elderly is a factor in health outcomes.
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    Cholesterol anyone ?

    Cholesterol is not the problem. Insulemia is.
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    Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases, 2019, McGregor et al

    There was a really interesting thread on PR a couple of years ago re purinergic signalling by necessay8. May be worth another read.
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    Physios for ME

    Joan McParlland had queried re twitter and was told it was not pertaining to NI, hence query.
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    Physios for ME

    Is this England and Wales only or UK wide?
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