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I've only used the type that helps your companion push the chair, when I first started struggling to walk. She said it was a big help, specially uphill. Other than that, my wheelies have always been more about getting out into the countryside than shopping etc (although I do depend on them for...

Yes, sure: https://www.biospace.com/article/theravance-shares-tumble-after-phase-iii-cardiovascular-asset-fails-to-hit-primary-endpoint/

Unfortunately the Phase III failed, and the company now faces making a lot of its staff redundant. I know that's how it sometimes goes with drug development, but it must be gutting to put that much effort in and end up with no drug and no job. You really have to feel for them.

I think we should expect them to tell patients what is known, without trying to explain what isn't. We know that ME patients say they can't do nearly as much activity as before they got ill, or sustain it for as long. That it takes much, much longer to recover from activity, and that if they...

This is the main challenge with scooters. You not only need to tense your legs to keep your balance, you have to hold them in position too. Relaxed, they tend to flop outwards at the knee, which would mean tensing your core to hold you upright instead. It's the reason I went for a wheelchair...

Did you borrow a Tramper? They used to let them out at two or three of the Peak District cycle hire places; I last took one all the way around Ladybower before I got my own wheelie. They're hard work compared to a wheelchair, but it is so wonderful to get out. Hopefully you won't feel battered...

One of the things we need to include is a full picture of the impact of treatment on our lives. We've all cut activities out when we've been feeling worse, and often they're things we'd never think to mention to a doctor: fewer phone calls to friends and family, not vacuuming for ages...

Well, I've got Chinese sage in my garden, and I'm sure I've seen milkwort growing on the allotments...could make myself a small fortune!

Or that we need more research on connective tissue diseases, for that matter; there seems to be really quite a lot of research about them. Why can't we just have more research on something we've all actually got?

Does he believe all of them are partly caused by the mind? Including Parkinson's, dementia, rheumatoid disease, etc? Or is just the ones we can't yet show on imaging or blood tests?

The road to Damascus? OK fair enough, it is a ridiculous idea.

I wondered about that – 78 people with such rare disorders being referred to one clinic does seem surprising.

They're not claiming this, though. The patients were referred to the clinic with idiopathic fatigue and exercise intolerance; none of them appear to have been diagnosed with ME/CFS prior to referral, and the study doesn't suggest that any were found to have ME/CFS after testing. The...

No; as far as I can see, none of the patients was diagnosed with ME/CFS. However, 81% had a fibromyalgia diagnosis. Given appropriate testing, it wouldn't surprise me if a small proportion of ME patients did have some kind of metabolic disorder. It would be fantastic to see detailed screening...

Some really good ideas here. I realise it's not always feasible, especially in early exploratory studies, but we need to work towards better-sized cohorts too. With such a heterogeneous condition, can you read anything much from a study of fewer than 20 patients? (Especially when it's a...

When anyone purporting to be a scientist uses gender when they mean sex, I just stop reading. :rolleyes: Seems to have a good policy when it comes to this abstract.

It does sound as if it's a different condition to mine. I think retinal migraines only affect one eye, usually the same eye every time. This type of migraine is thought to be caused by blood vessels constricting in response to a trigger; mine usually seem to be triggered by hot weather or...

If you can only see the scotoma in one eye, it may be retinal migraine. I get these, but have never suffered from the headache forms of migraine. I sometimes get the scotoma alone, but other times the vision in the affected eye is also impaired, with sharp focus impossible. Retinal migraines...

It's a difficult one to pin down, as it can just mean that our brains are giving us duff information. We get bulletins telling us that we're too hot / too cold/ in pain, even though there's no physiological reason for those signals to be sent. It doesn't make the sensations any less...

They're designed for situations where a pathogen is or may be present, so the assumption is that everyone will be wearing protective masks. Outside those settings, people make choices as to the level of protection they feel they need. Most seem to think they need none at all now. I probably...