Such a brave, raw piece. My heart goes out to Gary and his family and friends.
I hope that he achieves all he wishes to achieve and finds solace . A brave, brave man .
This.
Millions missing has raised awareness hugely and got some positive mainstream reporting- in multiple countries.
Research is desperately needed but equally so is changing the sociomedical narrative that frames perceptions and interactions and challenges the status quo.
Change cannot be...
Coyne did a good riposte of ACEs .
Sadly they are embedded in multiple spheres of life here and education is particularly affected. Some teachers even use them as predictive tools. There are few people who have gone through life without adverse childhood events of some nature, but as applied it...
piece in Washington Post by Julie Reymeher, Jen Brea and Brian Vastag
https://www.washingtonpost.com/health/long-haul-covid-patients/2020/10/23/ab7c5324-0712-11eb-9be6-cf25fb429f1a_story.html?fbclid=IwAR3bJ6QHbmTMzkg9YV6jEybvkGPpAgstVE0EdrCGbezeO9E6PArfTML57KY&mc_cid=a292066a60&mc_eid=7dd94a557c
Apologies if this sounds garbled ( and it could well be wrong ) , I looked at PPP some time ago when.looking at D Ribose as a means of reducing PEM.
Is the pentose phosphate pathway more energy intensive ? Ie net energy deficient and takes some time to generate ATP.
I have no doubt psychological stress can play a role, but THE role ?
PEM inducing stresses would seem more likely, especially if in a state of rolling PEM.
Thanks @Midnattsol .
I wondered if the lack of ATP upstream caused a mitochondrial feedback loop.
One complex is overproducing because the other is under producing .
It would be useful to know how many were female - other studies have flagged up a propensity for females to switch to aminos in preference to fat .
Also AMPK is a key signalling molecule which seems to have many functions , it modulates metabolism in many conditions including diabetes ...
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