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    Gary Burgess - The ME show, and updates about Gary's health.

    Such a brave, raw piece. My heart goes out to Gary and his family and friends. I hope that he achieves all he wishes to achieve and finds solace . A brave, brave man .
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    United Kingdom: News from Forward-ME Group

    This. Millions missing has raised awareness hugely and got some positive mainstream reporting- in multiple countries. Research is desperately needed but equally so is changing the sociomedical narrative that frames perceptions and interactions and challenges the status quo. Change cannot be...
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    A cohort study of whether parental separation and lack of contact [...] predicts disease severity [...] in young peoples ME/CFS, 2020, O'Donnell et al

    Coyne did a good riposte of ACEs . Sadly they are embedded in multiple spheres of life here and education is particularly affected. Some teachers even use them as predictive tools. There are few people who have gone through life without adverse childhood events of some nature, but as applied it...
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    Crowdfunding: Trial By Error [David Tuller]: Reporting on ME, CFS, ME/CFS, "medically unexplained symptoms," and related stuff, Fall 2020

    !Phew - relief abounds. The retraction of the pediatric paper shows how worthwhile this is . Thank you
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    Glycolytic impairment - what are the practical implications?

    would insulin resistance not also affect leptin and grehlin signalling and thus the hunger response- body has lost calibration of satiety?
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    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    piece in Washington Post by Julie Reymeher, Jen Brea and Brian Vastag https://www.washingtonpost.com/health/long-haul-covid-patients/2020/10/23/ab7c5324-0712-11eb-9be6-cf25fb429f1a_story.html?fbclid=IwAR3bJ6QHbmTMzkg9YV6jEybvkGPpAgstVE0EdrCGbezeO9E6PArfTML57KY&mc_cid=a292066a60&mc_eid=7dd94a557c
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    Do treatments for paediatric chronic fatigue syndrome improve pain? a systematic review, Ascough et al, 2020 G535(P)

    Each paper simply reinforces how little such pediatricians actually know. For any to be termed " expert" is denigration of the term
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    Apologies if this sounds garbled ( and it could well be wrong ) , I looked at PPP some time ago when.looking at D Ribose as a means of reducing PEM. Is the pentose phosphate pathway more energy intensive ? Ie net energy deficient and takes some time to generate ATP.
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    Early Growth Response Gene Upregulation in Epstein–Barr Virus (EBV)-Associated ME/CFS, Kerr, 2020

    I have no doubt psychological stress can play a role, but THE role ? PEM inducing stresses would seem more likely, especially if in a state of rolling PEM.
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    Thanks @Midnattsol . I wondered if the lack of ATP upstream caused a mitochondrial feedback loop. One complex is overproducing because the other is under producing .
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    It would be useful to know how many were female - other studies have flagged up a propensity for females to switch to aminos in preference to fat . Also AMPK is a key signalling molecule which seems to have many functions , it modulates metabolism in many conditions including diabetes ...
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    Would you not need to do this to avoid being in a catabolic state?
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