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Thanks Binkie, appreciate the kind words. Are people still participating, by completing the questionnaire and by sending us DNA samples? Yes, and we are grateful to everyone who does. Would we like to see even more people participating? Yes, absolutely. We will continue our efforts to promote...

"It takes money to do research and, increasingly, much of it comes from private donors and foundations, especially in the United States. Philanthropists provided 44% of research funding at US universities and non-profit research institutes in 2016, according to a 2018 post by the Science...

[This is general information on how NHS England is being re-organised, rather than anything specific to ME.] "NHS England have published “Guidance on developing the joint forward plan (JFP)”. This guidance supports integrated care boards (ICBs) and their NHS trusts and foundation trusts to...

News in Brief posts for w/c 9th Jan. Facebook: https://www.facebook.com/sci4me/posts/pfbid0347pqsVKFzLEUMDwwbcZQzNb9LATbBj7GZRPEe72WKDsxBAdanTgMTAbRK4pw81ffl Mastodon: https://med-mastodon.com/@s4me/109692518326247575 and published papers thread Facebook...

Abstract Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial dynamics in mitigating such processes and their impact on muscle fitness remain unaddressed. Here we...

Still enabling harm in 2023, Fatigue, post-exertional malaise and orthostatic intolerance: a map of Cochrane evidence relevant to rehabilitation... 2022 ARIENTI et al

Merged thread Full title: Fatigue, post-exertional malaise and orthostatic intolerance: a map of Cochrane evidence relevant to rehabilitation for people with post COVID-19 condition INTRODUCTION: Rehabilitation focuses on impairments, activity limitations and participation restrictions being...

Abstract Persistent fatigue is often reported in those with chronic musculoskeletal pain. Separately, both chronic pain and chronic fatigue contribute to physical and cognitive decline in older adults. Concurrent pain and fatigue symptoms may increase disability and diminish quality of life...

As far as I could see by searching here, these are the only two that the NIHR have funded and are still in progress. In progress: Measuring Health in Children with CFS/ME: Refinement, application and evaluation of new PROM (PEACH) in routine practice, Crawley et al Using activity tracking and...

Abstract Fibromyalgia (FM) is associated with sympathetically dominant dysautonomia, but the connection between dysautonomia and FM symptoms is unclear. Dysautonomia can be analysed with heart rate variability (HRV) and it has been proposed that FM patients comprise subgroups with differing...

Full title: The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients Summary Background Patients with inflammatory bowel disease (IBD) treated with anti-TNF therapy exhibit attenuated...

Abstract Background: COVID-19 is associated with higher morbidity and mortality in patients with chronic liver diseases (CLDs). However, our understanding of the long-term outcomes of COVID-19 in patients with CLD is limited. Methods: We conducted a multicenter, observational cohort study of...

Background and purpose: Long COVID with regard to the neurological system deserves more attention, as a surge of treated patients are being discharged from the hospital. As the dynamic changes in white matter after two years remain unknown, this characteristic was the focus of this study...

Chris and I spoke with Jackie from Long Covid Podcast before Christmas, and it was released today. Long Covid Podcast 67 - DecodeME - a chat with Prof Chris Ponting & Andy Devereux-Cooke "Episode 67 of the Long Covid Podcast is a chat with two wonderful people from the Decode ME genetics...

"The reviewer was not impressed with the paper written by Israeli brain researcher Idan Segev and a colleague from Switzerland. “Professor Idan,” she wrote to Segev. “I didn’t understand anything that you said.” Segev and co-author Felix Schürmann revised their paper on the Human Brain...

Scientists Make Progress in Decoding Genetics of Insomnia "A research effort involving researchers from Texas A&M University, the Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia (CHOP) has used human genomics to identify a new genetic...

Abstract Genome-wide association studies (GWAS) in humans have identified loci robustly associated with several heritable diseases or traits, yet little is known about the functional roles of the underlying causal variants in regulating sleep duration or quality. We applied an ATAC-seq/promoter...

Abstract Objectives Uncertainty regarding the legitimacy of functional neurological disorder (FND) remains among some health care professionals. Despite treatment guidelines and consensus recommendations, variability in clinical practice referral decisions persists. Evidence from other...

ABSTRACT Post-viral syndrome is a well-known medical condition characterized by different levels of physical, cognitive, and emotional impairment that may persist with fluctuating severity after recovering from an acute viral infection. Unsurprisingly, COVID-19 may also be accompanied by...

"On 6 December 2022, the European Commission approved the second work program of Horizon Europe for the years 2023-2024. In this article, we highlight several grants that may be relevant for scientists studying myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)."...