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And with a bit more luck Simon Wessely might expand even further on his deficiencies in trials methodology. Can someone remind me: I think SW had some sort of advisory role with PACE ... if so, what? Or have I got that wrong?

Now that is very good news. So if my understanding is right, this will be a full parliamentary debate. I'm guessing that by being a Backbench debate, that simply means backbenchers are allowed into the debate; hopefully it does not mean that only backbenchers can join in?! For non-UK people...

Is this a clue? Presumably analysis of such large numbers would only be feasible using modern computing power?

Possibly in one of those threads.

Yep. (Post #89)

https://www.s4me.info/threads/iime-letter-to-mark-baker-nice-re-cbt-get-as-recommended-treatments.1949/page-8#post-35003 https://www.s4me.info/threads/prof-sir-simon-wessely-the-life-scientific-bbc-radio-4-14-feb-2017.991/#post-29947 Does he really not see what a joke he is. Edit: Added...

Yes, it does with me. Trying to find it but no luck so far. Not the quote of @large donner's, something closer to what you said.

Quite. And given the trial had no blinding whatsoever, the researchers will have had strong indications how things were panning out quite early on. I mean, how likely is it really that they were not discussing along the way how things were going - their teams were collecting the data and were...

Also shows that the very word "fatigue' is the most inappropriate description for the illness, and also no doubt why it is the most preferred naming by the BPS people.

I would thing humans, like many other animals, have evolved to crave food when it is available, because food availability was far from continuous, but sporadic. In rare moments of plenty, piling on the calories beyond immediate requirements, would have been nature's energy storage mechanism, to...

And indeed indeterminate biases.

I suspect that in times past most people have not had any choice anyway. In evolutionary terms humans have not needed any significant built-in weight control mechanisms until very recently, because the effort required to acquire food, and the calorie intake of that food once acquired, have...

Which maybe warrants some discussion of what exactly do constitute incontrovertible objective outcomes for ME. Not nearly as straightforward as it might seem. Physical activity tested within a trial, may potentially be "exchanged" by doing less activity outside of the trial. Cognitive activity...

Quite so. In their world modification of people's perceptions is at the heart of their treatments, whose effectiveness they assess by measuring people's perceptions, which is of course wholly subjective. And knowing which treatment you are getting can itself help to modify perceptions, meaning...

I strongly suspect Tovey is not just saying that of his own volition, but likely echoing drip-feed whisperings that have been going on in his ear. Which in a way shows him to be even less qualified, because he should be above all that, and have the knowledge, confidence and courage to stand by...

May be some interesting bits in here ... https://handbook-5-1.cochrane.org/chapter_8/8_assessing_risk_of_bias_in_included_studies.htm

Ditto.

Brilliant @Trish. Why is it that so many of AfME's endeavours seem rooted in soliciting influence and promoting their name, and so very little to do with advocacy rooted in real science. Politics rather than substance.

I think this is very misleading, because these definitions relate to NICE's 2007 CG53 guideline, which is the very guideline being overhauled because it is flawed! I know Forward ME has their disclaimer, but I do not think it is anything like enough to avoid being misleading. I would prefer a...

Yes, @large donner, that quote alone of SW's clearly illustrates how the driving motivation for changing the outcome criteria was simply getting the results they wanted. And where is he coming from, by suggesting that so long as changes are reported properly, then they must be OK! If that were...