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I a going to EUROMENE this coming week but not CMRC. The programme looks to me about the best selection of what is going on in the UK and a bit of elsewhere you could do. The ME Biobank people at LSHTM are getting plenty of space. Newcastle and the UK Biobank are presenting and Chris Ponting is...

A good point but surely when they caught the flu they would have realised they had flu, and so would the doctors. So they just carried on as normal, having flu.

I am talking of systematic research studies which ought to have picked at least something up in some cases and my impression is that they did not.

But the tachycardia is driven by the autonomic system just as the blood vessel constriction is. If there was a blanket defect in the autonomic system there should be no tachycardia. There might be a selective defect so that constriction did not occur but tachycardia did, but then there should be...

This is what puzzles me. It is what makes me think of the situation in narcolepsy, and in particular the associated symptom of cataplexy. Cataplexy tends to be brought on by laughing and consists of complete inability to move. There is no suggestion by anybody that it is 'psychological' because...

I agree that sensitivity to sound and light are features of ME that you would not find in a random control group. But a neurologist would not usually call these 'sensory symptoms'. That is just a matter of convention but I think 'sensory symptoms' is confusing because it tends to imply other...

My memory of the original text is that it seems to refer to Wessely. It may be simply that Kohn made a slip in confusing the two names. I don't think it is material.

This has been noted before. Kohn was so familiar with 'John's' great work that he had forgotten his actual name.

Temperature control is hypothalamic but I am not sure it is autonomic. The response of the hypothalamus involves things like changing thyroid hormone secretion and shivering (which is somatic rather than autonomic). Orthostatic intolerance is often attributed to autonomic dysfunction but there...

Was thinking of a randomly chosen cohort, to see whether the incidence of sensory symptoms in ME could be considered more than one would find by chance in a random selection of people. If not there would be no reason to think it was part of the ME.

A little rhyming, or not, goes a long way from Eire to Japan.

There should be but I am not sure there is. When Ramsay talked of fatiguability he was obviously noting a real symptom. However, my understanding is that electrophysiological studies do not demonstrate nerve of muscle impairment. The closest thing that I can think of that might explain what is...

797 or 0.8% I wish Estate Agents would charge as little as that.

It just struck me that it would be interesting to know how psychotherapists get on in a culture that believes in fate. I do not want anything I say to be taken judgmentally but what about those who believe that everything is the will of Allah? Or those who drive far too fast with a crucifix...

I think this is misconceived and tends to take things in the wrong direction. It is this sort of analysis that makes me think we should stop referring to 'outbreaks of ME' documented in the past, because they probably tell us nothing important about the illness people suffer from today. The...

Yes, I am afraid her list of calling outs looks pretty tame to me. And where it counts, off target.

I will be seeing them next week.

Yes, I am pretty sure the original application period was the same as for lay members. It looks a bit as if they have had no takers. Luis Nacul would be a good person to be involved. Or indeed Caroline Kingdon, the research nurse specliaist at LSHTM

Paul Dieppe used to be a quality biomedical scientist and was a close friend of mine in the 1970s. He was a hostage in Kuwait in 1990. Some time after that - maybe 1994, he asked me if I was interested in his chair in Bristol as he was moving into administration. I think something major had...

Do we know why Dieppe retired? He should have known there were problems from the outset.